Oral cancer diagnosis & therapy, Pulp cell-derived iPS cell biology, Regenerative & reconstructive oral maxillofacial surgery, Developmental disorders, Cell therapy for oral cancer
From 2000 to 2005, we performed a molecular-epidemiological study of oral and maxillofacial disease in the residents of the SNTS area in Kazakhstan, former Soviet Union, and found low-dose radiation exposure severely affects on oral and maxillofacial development in the residents living around SNTS.
We succeeded in regenerating jaw, eye and tooth using undifferentiated pluripotent cells derived from Xenopus and mice. We have successfully treated oral cancer patients with NK/LAK cell therapy and photodynamic therapy. We are developing a novel therapeutic and diagnostic modality targeted to newly identified Cancer Stem cells from oral squamous cell carcinomas (Fig. 1). We have successfully established iPS cells from patients with genetic disorders in the oral and cranio-maxillofacial region in serum- and feeder-free culture (Fig. 2).