Molecular Oral Medicine & Maxillofacial Surgery

【Research Keyword】
Oral cancer diagnosis & therapy, Pulp cell-derived iPS cell biology, Regenerative & reconstructive oral maxillofacial surgery, Developmental disorders, Cell therapy for oral cancer

【Recent highlights】
From 2000 to 2005, we performed a molecular-epidemiological study of oral and maxillofacial disease in the residents of the SNTS area in Kazakhstan, former Soviet Union, and found low-dose radiation exposure severely affects on oral and maxillofacial development in the residents living around SNTS.
We succeeded in regenerating jaw, eye and tooth using undifferentiated pluripotent cells derived from Xenopus and mice. We have successfully treated oral cancer patients with NK/LAK cell therapy and photodynamic therapy. We are developing a novel therapeutic and diagnostic modality targeted to newly identified Cancer Stem cells from oral squamous cell carcinomas (Fig. 1). We have successfully established iPS cells from patients with genetic disorders in the oral and cranio-maxillofacial region in serum- and feeder-free culture (Fig. 2).

【Education】
We lecture in Molecular Oral Medicine and Maxillofacial Surgery at the graduate school level. At the undergraduate level, we teach oral surgery, maxillofacial surgery, applied oral medicine and practical clinical course work. At the hospital including outpatients and inpatients wards, we diagnose and treat patients with deformities, growth abnormalities, inflammation, trauma, and tumors (benign/malignancy) in the oral and maxillofacial regions.

【Research】
We conduct the following research to develop new methods of diagnosis and therapy for diseases as described above:

  1. Gene/molecular diagnosis and therapy for oral cancer and salivary gland tumors. (Cancer stem cells, growth factors, growth factor receptors, invasion and metastasis, tumor angiogenesis, and molecular/gene target therapy).
  2. The molecular/genetic diagnosis and therapy for oral and cranio-maxillofacial deformities.
  3. Establishment and characterization of human induced pluripotent stem (iPS) cells derived from human pulp cells in serum- and feeder-free cell culture.
  4. Generation of human induced pluripotent stem (iPS) cells derived from patients with genetic disorders in the oral and cranio-maxillofacial region in serum- and feeder-free culture to elucidate the molecular mechanism involved in the disease.
  5. Purification of biologically active factors from marine organism.
  6. Photodynamic therapy for oral cancer.
  7. Immune cell therapy for oral cancer by using NK/lymphokine-activated killer (LAK) cells.
  8. Jaw and tooth regeneration in vitro.
  9. Molecular-epidemiological study of oral and maxillofacial disease among residents of Semipalatinsk Nuclear Test Site (SNTS) area in Kazakhstan.

                                     Fig.1

                                     Fig.2


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