Pharmaceutics and Therapeutics

Prof. Mikihisa Takano

【Research Keyword】
Drug metabolism and disposition, membrane transport, transporter, endocytosis receptor, drug toxicity, epithelial-mesenchymal transition

【Recent highlights】
Prof. Takano chaired 32nd JSSX (Japanese Society for the Study of Xenobiotics) Annual Meeting in Tokyo, from November 29th to December 1st, 2017, which would have significantly contributed the progress in this research field.  Prof. Takano was invited as a speaker to “The 8th Meet the Experts Transporter Conference”, which was held in Budapest, Hungary, on April 25-27, and gave a keynote presentation.

Profiles of Faculty and Research Scholars

・Biopharmaceutics: Membrane transport, absorption, distribution, metabolism, and excretion of drug
・Pharmacokinetics: Pharmacokinetic parameters, mathematical fundamentals in pharmacokinetics, and application of pharmacokinetics to dosage regimens
・Industrial pharmaceutics (Pharmaceutical technology): Physicochemical properties of pharmaceutical materials, typical drug products, drug product design, and drug delivery system
・Students’ practice of pharmaceutics: Stability of drug products, lipophilicity, plasma protein binding, intestinal absorption, renal excretion, and therapeutic drug monitoring (TDM)
・Education for undergraduate and graduate students in the laboratory: Seminar and research on molecular biopharmaceutics, pharmacokinetics, and drug-induced toxicity


  1. Expression and function of membrane transporter and endocytosis receptor in the alveolar epithelial cells
  2. Drug-induced epithelial-mesenchymal transition as a cause of lung fibrosis and its prevention
  3. Expression and function of membrane transporter in human blood cells

【Photo explanation】 Structure of cell membrane and transporter-mediated influx and efflux of drugs across the cell membrane

【Photo explanation】 TGF-β1-induced EMT and related changes in cell morphology and actin filament structure in alveolar epithelial cells