Pharmaceutics and Therapeutics

Prof. Mikihisa Takano

【Research Keyword】
Drug metabolism and disposition, membrane transport, transporter, innate immune response, drug-induced lung injury, alveolar epithelial cells, epithelial-mesenchymal transition, pulmonary fibrosis

【Recent highlights】
In FY2019, Professor Takano, Associate Professor Yumoto, and Assistant Professor Kawami and a graduate student presented their works at the international conferences Eurotox 2019 (Helsinki, Finland), ISSX2019 (Portland, USA), and PharmSci360 (San Antonio, USA), respectively. Unfortunately, due to the spread of Cov-19, all international conferences scheduled to attend or make presentations in FY2020 have been canceled or postponed, but 13 presentations have been made at domestic conferences held online.

Profiles of Faculty and Research Scholars

【Education】
・Biopharmaceutics: Membrane transport, absorption, distribution, metabolism, and excretion of drug
・Pharmacokinetics: Pharmacokinetic parameters, mathematical fundamentals in pharmacokinetics, and application of pharmacokinetics to dosage regimens
・Industrial pharmaceutics (Pharmaceutical technology): Physicochemical properties of pharmaceutical materials, typical drug products, drug product design, and drug delivery system
・Students’ practice of pharmaceutics: Stability of drug products, lipophilicity, plasma protein binding, intestinal absorption, renal excretion, and therapeutic drug monitoring (TDM)
・Education for undergraduate and graduate students in the laboratory: Seminar and research on molecular biopharmaceutics, pharmacokinetics, and drug-induced toxicity

【Research】

  1. Study on the expression and function of transporters in alveolar epithelial cells
  2. Study on the innate immune response in lung alveolar region
  3. Analysis of the mechanism of drug-induced epithelial-mesenchymal transition of alveolar epithelial cells and development of biomarkers and prevention strategy for drug-induced pulmonary fibrosis.

【Photo explanation】 Structure of cell membrane and transporter-mediated influx and efflux of drugs across the cell membrane

【Photo explanation】 TGF-β1-induced EMT and related changes in cell morphology and actin filament structure in alveolar epithelial cells


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