endoplasmic reticulum stress, autophagy, drug discovery, neurodegenerative disease, metabolic disease, alzheimar's disease, diabetes, obesity
We recently found that ER stress may be involved in pathophysiology of leptin resistance in obesity (Mol Pharmacol. 2008,74:1610-9.). We also found that flurbiprofen may be able to ameliorate leptin resistance through attenuating ER stress (EMBO Mol. Med. 2014, 6:335-46).