Research Center for Genome Editing

Goals

Realization of the "Dreamy Future" of Genome Editing.

Based on the excellent performance in genome editing research by the Engineered Nuclease Project Research Center at Hiroshima University, we aim to generate engineered nucleases of Japanese origin and develop new genome editing technologies that can help in understanding various life phenomena and can be applied to areas such as breeding and regenerative medicine. In addition, our goal is to improve the level of life science research in Japan and boost the biotechnology industry by providing tools and technologies for genome editing from the Genome Editing Consortium centered around Hiroshima University.

Background

Genome editing is a form of genetic engineering technology to induce various types of mutations, such as deletion, insertion, gene knock-in, etc., in targeted genes using artificially generated restriction enzymes called engineered nucleases, which can be customized to manipulate DNA sequences as desired.

Genome editing is attracting increasing attention as a next-generation bio-technology tool that enables manipulation of targeted genes in several organisms including those that were previously non-permissive.

Plans

An initiative to create a world leader in Genome Editing Research

Outcomes

  1. Development of basic genome editing technology in Japan: Using artificially generated nuclease, acceleration of genome editing technology development with high flexibility, ranging from a single base to chromosomal level editing.
  2. Establishment of a genome editing platform: Making it possible to easily alter genes within organisms (animals and plants), microbes, and cultured cells
  3. Development of the Biomedical field: Developing altered microbes, disease-models in cells and animals (frog, mouse, and rat), and propagating research which could be applied to regenerative medicine
  4. Development of the plant field: Using genome editing, including Knock-out, to generate a wide variety of plants
  5. Support to genome and data editing: Streamlining and consolidating data collection and analysis at our research center
  6. Human resource development in the field of genome editing: Accelerating development by fostering research


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