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Scientists observe that one molecule increases liposarcoma tumor cell spread and aggression while another molecule from the same family decreases migration and cell proliferation.
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Researchers at Hiroshima University have found that different levels of two molecules of the same family--TIMP-1 and TIMP-4--can influence prognosis of liposarcoma.
High levels of TIMP-1 lead to a poor prognosis while high TIMP-4 indicates a less severe form of liposarcoma. This study, published in Carcinogenesis 10th May 2019, described the molecules' mechanism of action through the YAP/TAZ pathway. Further research can lead to new treatments and better methods of diagnosis for liposarcoma.
TIMP-4 prevents YAP/TAZ from entering the tumor cell nucleus. It is then stored in the cytoplasm and degraded. TIMP-1 activates YAP/TAZ and leads to cell proliferation.
Full bibliographic information
Title: The transition of tissue inhibitor of metalloproteinases from -4 to -1 induces aggressive behavior and poor patient survival in dedifferentiated liposarcoma via YAP/TAZ activation
Authors: Shrestha, M., Ando, T., Chanbora, C., Sakamoto, S., Nishisaka, T., Ogawa, I., Mutsumi Miyauchi, M., Takashi Takata, T.
Research Planning Office, Hiroshima University
By Emma Buchet
Originally Published on May 13, 2019