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[Research] A Simpler Way to Choose the Sex of Offspring by Separating X and Y Sperm

Differential gene activity by the two sex chromosomes allows X-bearing sperm to be slowed down


Both X sperm and Y sperm swim to oocyte for fertilization. The probability to bind and penetrate to oocyte is same; however, under the specific condition, the ration of X sperm and Y sperm to reach to oocyte is changed. Credit: Gerd Altmann from Pixabay

A simple, reversible chemical treatment can segregate X-bearing sperm from Y-bearing sperm, allowing dramatic alteration of the normal 50/50 male/female offspring ratio, according to a new study by Masayuki Shimada and colleagues at Hiroshima University, published on August 13 in the open-access journal PLOS Biology. The study was performed in mice, but the technique is likely to be widely applicable to other mammals as well.


Full bibliographic information

Journal: PLOS Biology
Title: Activation of Toll-like receptor 7/8 encoded by the X chromosome alters sperm motility and provides a novel simple technology for sexing sperm
Authors: Takashi Umehara, Natsumi Tsujita, Masayuki Shimada

[Media Contact]
Professor Masayuki Shimada
Graduate School of Integrated Sciences for Life, Hiroshima University

E-mail: mashimad*hiroshima-u.ac.jp (Please replace * with @)