Cellular Biology

Prof. Satoshi Tashiro

【Research Keyword】
Ionizing radiation, chromosome abnormalities, DNA repair, higher order nuclear architectures

【Recent highlights】
Recently, we showed that some factors associated with higher order nuclear architectures are involved in the regulation of homologous recombinational repair of DNA double strand breaks induced by ionizing radiation. (FASEB J. 2015:29(6):2514-25., Genes Cells. 2015:20(9):681-94., Int J Radiat Oncol Biol Phys. 2014:15;89(4):736-44.)

【Department of Cellular Biology】 

Name Title
Satoshi Tashiro Professor
Keiei Son Associate Professor
Yasunori Horikoshi Assistant Professor
Yasuha Kinugasa Assistant Professor

We teach molecular biology in medical school, and molecular cell biology, biochemistry and radiation biology in graduate school.

The goal of our department is to clarify the mechanism underlying the formation of chromosomal abnormalities induced by various types of genomic stress, especially ionizing radiation. For this purpose, we are studying the dynamic organization of nuclear functions in response to DNA damages, such as DNA double strand breaks (DSBs). We have already established the UVA laser microirradiation system to induce DSBs in a restricted nuclear region. We are now studying the dynamics of DNA repair proteins and reorganization of chromatin in response to DNA damage induced by ionizing irradiation or UVA-microirradiation using the live imaging system and the multicolor immunofluorescence technique. Molecular mechanisms underling the formation of chromosome abnormalities and DNA damage induced nuclear foci are most important topics in our lab.