Cellular Biology

Prof. Satoshi Tashiro

【Research Keyword】
Ionizing radiation, chromosome abnormalities, DNA repair, higher order nuclear architectures

【Recent highlights】
The low-dose chest CT scans used in lung cancer screening do not appear to damage human DNA, according to a study of DNA damage and chromosome aberrations. The results could help allay fears that such screenings will lead to an increase in radiation-induced cancer. (Biological Effects of Low-Dose Chest CT on Chromosomal DNA. Sakane H, et al. Radiology. 2020 May;295(2):439-445)
We reported that DNA damage signaling factor ATM regulates the activity of chromatin remodeling complex to prevent chromosome aberrations. (Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations. Sun J., et al. Elife. 2018 May 8;7. pii: e32222.)

【Department of Cellular Biology】 

Name Title
Satoshi Tashiro Professor
Keiei Son Associate Professor
Yasunori Horikoshi Assistant Professor

We teach molecular biology in medical school, and molecular cell biology, biochemistry and radiation biology in graduate school.

The goal of our department is to clarify the mechanism underlying the formation of chromosomal abnormalities induced by various types of genomic stress, especially ionizing radiation. For this purpose, we are studying the dynamic organization of nuclear functions in response to DNA damages, such as DNA double strand breaks (DSBs). We have already established the UVA laser microirradiation system to induce DSBs in a restricted nuclear region. We are now studying the dynamics of DNA repair proteins and reorganization of chromatin in response to DNA damage induced by ionizing irradiation or UVA-microirradiation using the live imaging system and the multicolor immunofluorescence technique. Molecular mechanisms underling the formation of chromosome abnormalities and DNA damage induced nuclear foci are most important topics in our lab.