Experimental animals, Immunology, Genetic modification, Somatic cell cloning, Artificial chromosome, T cell, Allergy
We successfully generated cloned mice from CD4+ T cells expressing T cell receptor (TCR) reactive to a major allergen, house dust mite, for the first time (EMBO Rep, 18:885, 2017). They are not GMO, can be established within 2 months, and develop allergic inflammation within 3 days. Several characteristic mice and cells can be generated from the cloned mice. Our cloned mice technology may provide the breakthrough in immunological and radiological research.