【Major Papers of the Laboratory】
・A novel anticancer quinolone, (R)-WAC-224, has anti-leukemia activities against acute myeloid leukemia, INVESTIGATIONAL NEW DRUGS, 41(5), 751-760, 202310
・Peripheral T cell profiling reveals downregulated exhaustion marker and increased diversity in lymphedema post-lymphatic venous anastomosis, ISCIENCE, 26(6), 20230616
・Tatsuo Ichinohe, Hiroshi Takayama, Yasuharu Ezumi, Shigeru Yanagi, Hirohei Yamamura, Minoru Okuma: Cyclic AMP-insensitive activation of c-Src and Syk protein-tyrosine kinases through platelet membrane glycoprotein VI. J Biol Chem. 1995; 270(47):28029-28036. , 19951101

【Education】
Our department was created in 1959 as part of Radiation Biology Research Center of Hiroshima University,having been recognized as one of the oldest education/research units in RIRBM. Since its establishment, our mission has been focused on education and researches on diagnosis and clinical management of various types of hematologic neoplasms, bone marrow failure,and bleeding/thrombotic disorders. Always on the cutting-edge scientific/medical knowledge, we offer an individualized education program by “polylogue-based” hands-on approach.

【Research】
１．Ultra-high-resolution monitoring of human immune system using unbiased high-throughput sequencing of T-cell and B-cell receptors.
２．Clinical development of adoptive cellular therapy using gene-edited T-cells
３．Development of comprehensive cell therapy for acute and late radiation effects using bone marrow mesenchymal stromal cells.
４．Analysis of radiation-induced responses during early embryonic development of zebrafish.
５．Comprehensive research for improving quality of life in patients with hematologic malignancies.