Acute radiation injury and late-onset radiation effect, Hematopoietic stem cells, Leukemic stem cells
【Department of Stem Cell Biology 】
|Kazuhito Naka||Associate Professor|
|Yoshinori Ohno||Assistant Professor|
Hematopoietic insufficiency is one of the most serious problems in patients with acute radiation injury, while leukemia and the other malignancies are susceptible to those with late-onset radiation effect. In this program we deepen understanding of hematopoietic and leukemic stem cells and further instruct advanced technologies for analyzing these stem cell systems and molecular mechanisms supporting the activity. We aim to develop a new strategy for treating patients with hematopoietic insufficiency and the malignancies including leukemia.
１．Analysis of radiation effect on the hematopoietic system
２．Analysis of molecular bases supporting the hematopoietic stem cell activity to aim developing a new strategy for manipulating hematopoietic stem cell activity
３．Analysis of molecular bases underlying leukemic stem cells to aim developing a new strategy for eradicating leukemic stem cells