【Research Keyword】
Surgical oncology, Esophageal cancer, Lung cancer, Breast cancer, Mesothelioma, Surgery, Endoscopic surgery, Thoracosocopic surgery, Chemotherapy, Chemoradiotherapy, Immunotherapy, Oncogenes, Gene therapy, PET, Biomarker, Liquid biopsy
【Recent highlights】
In the recent years, circulating microRNAs (miRNAs) have attracted a lot of attention and interest in the field of cancer biomarkers. Our large-scale data of each carcinoma may provide a new diagnostic approach for the early detection of each carcinoma and for forecasting prognosis of each carcinoma.

【Department of Surgical Oncology】
Name | Title |
OKADA Morihito | Professor |
MIYATA Yoshihiro | Associate Professor |
SIGEMATSU Hideo | Lecturer |
SASADA Shinsuke | Assistant Professor |
MIMAE Takahiro | Assistant Professor |
【Major Papers of the Laboratory】
・Segmentectomy for ground-glass-dominant lung cancer with a tumour diameter of 3 cm or less including ground-glass opacity (JCOG1211): a multicentre, single-arm, confirmatory, phase 3 trial, Lancet Respir Med, 11(6), 540-549, 202306
・First-line nivolumab plus ipilimumab or chemotherapy versus chemotherapy alone in advanced esophageal squamous cell carcinoma: a Japanese subgroup analysis of open-label, phase 3 trial (CheckMate 648/ONO-4538-50), ESOPHAGUS, 20(2), 291-301, 202304
・Pembrolizumab plus chemotherapy in Japanese patients with metastatic squamous non-small-cell lung cancer in KEYNOTE-407, CANCER SCIENCE, 114(8), 3330-3341, 202308
【Education】
The goals of the education on our department are to learn the diagnostics and therapeutics on the field of surgical oncology, especially lung cancer, breast cancer and esophageal cancer under the guidance of the mentor. Our department Research activities have been particularly focused on experimental and clinical aspects of multidisciplinary treatment of cancer. Our staff members play important roles as opinion-leaders in surgical oncology in Japan. The number of publications and presentations are increasing year by year.
【Research】
The main research subjects can be summarized as follows:
1.New surgical approaches for pulmonary, gastrointestinal and mammary malignancies
2.Multimodal therapy for cancer including chemotherapy, chemoradiotherapy and immunotherapy
3.Oncogenes and gene therapy for cancer
4.Quality of life in cancer patients
5.Cancer immunology and biological reactions
6.New diagnostic approaches for malignancies
7.Late onset effects of the atomic bomb explosion in terms of malignancies.

【Photo explanation】RATS (Robot-Assisted Thoracic Surgery) adopted for lung cancer, esophageal cancer and mediastinal tumor

【Photo explanation】Surgical technique seminar regularly held for new residents

【Photo explanation】Scene at the laboratory