Biomedical Chemistry

Prof. MORIWAKI Kenta

【Research Keyword】
Cell death, Necrosis, Plasma membrane damage, Inflammation, Cancer, Inflammatory disease

【Recent highlights】
1. Identified pH-dependent molecular protonation as a post-translational modification that regulates the activity of the cell death regulator RIPK1. (Moriwaki K, et al., Sci Signal, 2020)
2. Discovered that specific glycosphingolipids regulate death ligand-induced cancer cell death. (Fukuoka T, Moriwaki K, et al., Oncogene, 2022)
3. Elucidated the role of RIPK1 in dendritic cell survival and uncovered mechanisms of peripheral tissue inflammation observed in patients with RIPK1 gene mutations using a mouse model. (Moriwaki K, et al., Mucosal Immunol, 2022)

Profiles of Faculty and Research Scholars

【Major Papers of the Laboratory】
・Dynamic movement of the Golgi unit and its glycosylation enzyme zones, Nature Communications, 15(1), 4514, 20240527
・A high-sensitivity ELISA for detection of human FGF18 in culture supernatants from tumor cell lines, Biochemical and Biophysical Research Communications, 675, 71-77, 202310
・EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts., Blood advances, 20230412

【Education】
Undergraduate Courses:
・Introduction to Medical Research (1st-year medical students)
・Biochemistry II (2nd-year medical students)
・Clinical Biochemistry (2nd-year nursing students in the School of Health Sciences)
Through lectures and practical sessions, the course aims to provide students with a solid understanding of the concept of biochemistry.
Graduate Courses:
・Lectures in Physiology and Biological Chemistry
・Supervision in Graduate Research
Our graduate training emphasizes acquiring essential experimental techniques, developing logical thinking skills, reading scientific literature in English, and delivering effective research presentations (including in English). We encourage students to take the initiative in conducting research and aim to foster independent researchers who can excel and thrive on the international stage.

【Research】
Our laboratory focuses on understanding the molecular mechanisms underlying:
 1. The determination of cell fate—life or death
 2. The behavior of cells under the threat of death and their impact on surrounding environments

By investigating these mechanisms, we aim to enhance the understanding of homeostatic maintenance, and the pathology of inflammatory diseases and cancer, thereby contributing to the development of novel therapeutic approaches. We employ a wide range of techniques, including biochemistry, molecular biology, cell biology, immunology, genetic engineering, and the use of genetically modified mice, to pursue the following research topics:
 ・Molecular mechanisms of plasma membrane damage response and their significance in inflammation
 ・Molecular mechanisms of cellular memory of plasma membrane damage, and their significance in inflammatory pathology
 ・Molecular mechanisms of regulated necrosis and their significance in inflammatory pathology
 ・Intracellular structural dynamics of functional amyloids regulating cell fate and inflammation 
 ・Development of cell death control methods and their application in cancer therapy


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