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【Research Keyword】
mutagenesis, carcinogenesis, DNA damage, DNA repair, gene therapy, gene correction, genome editing, iPS cells
【Recent highlights】
We recently found induction of “action-at-a-distance mutations” by a damaged base. Moreover, we established a visualization system for damaged nucleotides and found a novel factor for promoted gene correction.
【Major Papers of the Laboratory】
・Paradoxical role of the major DNA repair protein, OGG1, in action-at-a-distance mutation induction by 8-oxo-7,8-dihydroguanine, DNA REPAIR, 111, 202203
・Positive Feedback System Provides Efficient and Persistent Transgene Expression, MOLECULAR PHARMACEUTICS, 7(4), 1125-1132, 2010
・Effects of base excision repair proteins on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) paired with cytosine and adenine, DNA REPAIR, 9(5), 542-550, 2010
【Education】
(For undergraduates) Quantitative analysis using chemical reactions (volumetric analysis); instrumental analysis; analyses of medicines.
(For graduate students) Overview of nucleic acids; mechanisms of high fidelity DNA replication; nucleic acid medicines.
【Research】
１．Mutagenesis and carcinogenesis induced by DNA damage.
２．Suppression of mutagenesis by DNA repair.
３．Gene therapy by gene correction (genome editing).
４．Mutations and genome stability in iPS cells.
５．Visualization system for damaged nucleotides.
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