Nucleic Acids Biochemistry

Prof. Hiroyuki Kamiya

【Research Keyword】
mutagenesis, carcinogenesis, DNA damage, DNA repair, gene therapy, transgene expression, gene correction, genome editing, iPS cells

【Recent highlights】
We recently found induction of “action-at-a-distance mutagenesis” by a damaged base when DNA-related enzymes were knocked-down. Moreover, we found a novel, unexpected factor for promoted gene correction and systems for efficient and persistent transgene expression.

Profiles of Faculty and Research Scholars

(For undergraduates) Quantitative analysis using chemical reactions (volumetric analysis); instrumental analysis; analyses of medicines.
(For graduate students) Overview of nucleic acids; mechanisms of high fidelity DNA replication; nucleic acid medicines.

1.Mutagenesis and carcinogenesis induced by DNA damage.
2.Suppression of mutagenesis by DNA repair.
3.Gene therapy by gene correction (genome editing).
4.Gene therapy by transgene expression.
5.Mutations and genome stability in iPS cells