Attendance at the 8th Mini-Symposium on The Blood-Brain Barrier
I attended the 8th Mini-Symposium on The Blood-Brain Barrier held in Szeged, Hungary, from March 25 to 28, 2026, and presented a poster titled “Integrated proteomic analysis of resected tumor tissues and longitudinally collected plasma from patients with glioblastoma.”
Glioblastoma (GBM) is a highly aggressive brain tumor that significantly alters the central nervous system environment. Investigating the dynamic changes of the blood-brain barrier (BBB) under pathological conditions and its interaction with the systemic circulation using proteomics is crucial for understanding disease progression and identifying potential biomarkers. During the poster session, I presented the core of our research: a comprehensive proteomic study conducted on both longitudinally collected plasma and resected tissue samples using high-precision absolute quantitative SWATH-MS (Sequential Window Acquisition of all Theoretical Mass Spectra).
I had in-depth discussions with researchers and scholars from various countries. Participants showed great interest in our application of advanced omics approaches to study BBB-related alterations and systemic interactions and offered valuable suggestions for further data validation and future experimental designs.
In addition, I engaged in meaningful exchanges with international experts on several cutting-edge topics, such as the development of novel 3D in vitro BBB models (e.g., microfluidics and organ-on-a-chip), the role of extracellular vesicles in monitoring GBM treatment outcomes across the BBB, and emerging strategies for crossing the brain's protective barrier for targeted drug delivery. The symposium fostered a rich academic atmosphere, showcasing the rapid progress and diverse development trends in global blood-brain barrier research, which greatly broadened my academic perspective.
Finally, I would like to express my heartfelt gratitude to Professor Uchida, Dr. Hashimoto, and all members of the Molecular System Pharmaceutics laboratory for their guidance and support, as well as to Hiroshima University for providing the opportunity and financial support to participate in this international conference.

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