Anatomy and Developmental Biology

Prof. Koji Ikegami

【Research Keyword】
Cilia, cytoskeleton, extracellular vesicles, cell migration, cell division, stress response, circadian rhythm, body wall formation, imaging, cell biology, developmental biology

【Recent highlights】
We recently established a new technique that enables to study localization and function of proteins with few artifacts caused by overexpression (Ijaz & Ikegami. Cell Struct Funct 2021). We are getting highly clear and solid results regarding above keywords with the new technique. A student received an award in the student presentation competition of a research conference. 

Profiles of Faculty and Research Scholars

【Education】
Undergraduate education: lectures of “human body anatomy for human understanding”, “systematic anatomy”, and “embryology”, and practices of “human body anatomy practice” and “osteology practice”
Graduate school education: lecture of “human anatomy”, and practices of “special seminar” and “special research”

【Research】
We are conducting genome editing and microsurgery on cultured cells, mouse individuals, and chick embryos to investigate how cells, cell populations, and tissues change, and the contribution of molecules, intercellular information, stress, and circadian rhythms to these changes, using microscopy and omics. The following themes are in progress.

  1. Novel morphological changes of cilia in cell-to-tissue communication
  2. Discovery of novel extracellular vesicles and analysis of their histological and morphological functions
  3. Morphological analysis of functional regulation of polarized structures by cytoskeletal post-translational modifications
  4. Structural and functional changes induced by stress and circadian rhythms
  5. Understanding biological evolution by focusing on gametogenesis
  6. Dynamics of lateral plate mesoderm cells in body wall formation during chick embryogenesis
  7. Development of new methods for morphological studies

 

【Photo explanation】  Primary cilium, and the release of its tip


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