Home【Research Keyword】
Antigen receptor, Development of lymphocytes, Immunodeficiency, Lymphoma, Immune surveillance, Gene therapy, Allergy, Autoimmune disease
【Recent highlights】
・Carried out Crowdfunding for the development of next generation neutralizing antibodies (2021.7-9).
・Developed a technology and neutralizing antibodies which are highly effective against SARS-CoV-2 variants (2021.5.14 Press release; Patent application).
・Acute EBV infection animal model and EBV associated primary immunodeficiency disease model, which are useful for developing gene therapy, are established (2016 PNAS).
・We first demonstrated that expression of single EB virus gene, LMP1, is sufficient for induction of B cell lymphoma and host immune surveillance (2012 Cell).
・We found that ERK MAPK signal is essential for B cell development through regulating cell division associated with immunoglobulin rearrangement, and moreover, antibody secreting plasma cell formation (2008 Immunity; 2011 Science Signal).
【Major Papers of the Laboratory】
・Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants, Commun. Biol., 6(1), 395, 20230411
・Vaccination with the Omicron spike RBD boosts broadly neutralizing antibody levels and confers sustained protection even after acquiring immunity to the original antigen, Int. Immunol., 35(4), 197-207, 20230404
・Concomitant Cytotoxic Effector Differentiation of CD4(+) and CD8(+) T Cells in Response to EBV-Infected B Cells, Cancers, 14(17), 4118, 20220825
【Education】
School of Medicine: Lecture and practice of "Immunology" and "Parasitology" (1st/2nd grade). Practice for medical research in Immunology (4th grade).
Graduate School: Lecture for professional immunology. Training of performing experiments and writing paper for thesis.
【Reseach】
We promote research to understand principle of immune system focusing on antigen receptor signal and programming in lymphocytes, and moreover, develop therapy of immunodeficiency, cancer, allergy, and autoimmune diseases.
Major topics:
- The role of antigen receptor and mediated signals in immune system.
- The control mechanism for immune cell division limit and immortalization of immune cells.
- The mechanism to regulate lifespan of immune cells.
- Lymphoma development and immune surveillance to cancer cells or virus-infected cells.
- The mechanism for allergic disease development and induction of tolerance.
- Gene therapy to rescue immunocompromised congenital disease patients.
Members of Immunology (2021 Apr)
Tomoharu Yasuda, Ph.D.
Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University
1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan
Phone. +81-82-257-5175
E-mail. yasudat[at]hiroshima-u.ac.jp
(Please replace the “[at]” with “@”)
