Immunology

Prof. Tomoharu Yasuda

【Research Keyword】
Antigen receptor, Development of lymphocytes, Immunodeficiency, Lymphoma, Immune surveillance, Gene therapy, Allergy, Autoimmune disease

【Recent highlights】
・We found that ERK MAPK signal is essential for B cell development through regulating cell division associated with immunoglobulin (Ig) rearrangement, and moreover, antibody secreting cell (plasma cell) formation (2008 Immunity; 2011 Science Signal).
・We first demonstrated that expression of single EB virus gene, LMP1, is sufficient for induction of B cell lymphoma and host immune surveillance (2012 Cell).
・Acute EBV infection animal model and EBV associated primary immunodeficiency disease model, which are useful for developing gene therapy, are established (2016 PNAS).

Profiles of Faculty and Research Scholars

【Education】
School of Medicine: Lecture and practice of "Immunology" and "Parasitology" (2nd grade). Practice for medical research in Immunology (4th grade).
Graduate School: Lecture for professional immunology. Training of performing experiments and writing paper for thesis.

【Reseach】
We promote research to understand principle of immune system focusing on antigen receptor signal and programming in lymphocytes, and moreover, develop therapy of immunodeficiency, cancer, allergy, and autoimmune diseases.
Major topics:

  1. The role of antigen receptor and mediated signals in immune system.
  2. The control mechanism for immune cell division limit and immortalization of immune cells.
  3.  The mechanism to regulate lifespan of immune cells.
  4.  Lymphoma development and immune surveillance to cancer cells or virus-infected cells.
  5. The mechanism for allergic disease development and induction of tolerance.
  6. Gene therapy to rescue immunocompromised congenital disease patients.

Members of Immunology (2019 Sep)


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