【Research Keyword】
Antigen receptor, Development of lymphocytes, Immunodeficiency, Lymphoma, Immune surveillance, Gene therapy, Allergy, Autoimmune disease
【Recent highlights】
・Carried out Crowdfunding for the development of next generation neutralizing antibodies (2021.7-9).
・Developed a technology and neutralizing antibodies which are highly effective against SARS-CoV-2 variants (2021.5.14 Press release; Patent application).
・Acute EBV infection animal model and EBV associated primary immunodeficiency disease model, which are useful for developing gene therapy, are established (2016 PNAS).
・We first demonstrated that expression of single EB virus gene, LMP1, is sufficient for induction of B cell lymphoma and host immune surveillance (2012 Cell).
・We found that ERK MAPK signal is essential for B cell development through regulating cell division associated with immunoglobulin rearrangement, and moreover, antibody secreting plasma cell formation (2008 Immunity; 2011 Science Signal).