Morpho-pathological genomics, Molecular diagnosis, Systemic analysis of genome, transcriptome and epigenome, Gastrointestinal cancer, Urological cancer, Novel diagnostic and therapeutic target, non-coding RNA, Cancer stem cell, Organoid, Genome-editing
Pathology is an integrated medical science that studies the causes and mechanisms of disease, and is the foundation of medical science and practice. There are two main pillars in pathology; pathological diagnosis and experimental pathology. We place equal emphasis on both fields at our laboratory, and widely contribute to clinical practice and development of advanced medicine. Through molecular pathological analyses of gastrointestinal and urological cancers, we have identified several novel diagnostic and therapeutic targets such as REGIV, OLFM4, SPC18 and PCDHB9, and the abnormal expression and biological function of the transcribed-ultraconserved regions such as Uc.416+A, UC.160+ and Uc.63+. We also identified mitotic kinesin gene family as a novel regulator of cancer stem cell properties. We have a research project using human organoid in combination with genome-editing to uncover the actual driver pathway and the mechanism of chemotherapy-resistance in gastrointestinal and urological cancer.