Molecular Pathology

Prof. Wataru Yasui

【Research Keyword】
Morpho-pathological genomics, Molecular diagnosis, Systemic analysis of genome, transcriptome and epigenome, Gastrointestinal cancer, Urological cancer, Novel diagnostic and therapeutic target, non-coding RNA, Cancer stem cell, Organoid, Genome-editing

【Recent highlights】
Pathology is an integrated medical science that studies the causes and mechanisms of disease, and is the foundation of medical science and practice. There are two main pillars in pathology; pathological diagnosis and experimental pathology. We place equal emphasis on both fields at our laboratory, and widely contribute to clinical practice and development of advanced medicine. Through molecular pathological analyses of gastrointestinal and urological cancers, we have identified several novel diagnostic and therapeutic targets such as REGIV, OLFM4, SPC18 and PCDHB9, and the abnormal expression and biological function of the transcribed-ultraconserved regions such as Uc.416+A, UC.160+ and Uc.63+. We also identified mitotic kinesin gene family as a novel regulator of cancer stem cell properties. We have a research project using human organoid in combination with genome-editing to uncover the actual driver pathway and the mechanism of chemotherapy-resistance in gastrointestinal and urological cancer.

Profiles of Faculty and Research Scholars

【Education】
Basic Pathology, Molecular Pathology, Diagnostic Pathology
The Department of Molecular Pathology practices pathological diagnosis, the core of diagnosis, and is training more pathologists, as well as conducting advanced and exploratory research, as deeply rooted as basic medicine. With these two missions, we offer higher education / pathologist education / training for researchers, hence matching individual traits. Therefore, we are creating an environment for individuals, who can learn to their maximum capability and integrate the diverse vectors into pathology education, in the same direction.

【Research】

  1. Morpho-pathological genomic analysis on gastrointestinal and urological cancer
  2. Development of novel diagnostics and therapeutics through transcriptome dissection and systemic genome/epigenome analysis of cancer
  3. Analysis of no-coding RNAs in cancer and its clinical implication
  4. Molecular basis of cancer stem cell and its relation with cancer metastasis and therapy-resistance
  5. Identification of novel driver pathway in carcinogenesis using organoid biology and genome-editing

【Photo explanation】 Laboratory


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