【Major Papers of the Laboratory】
・SPARC Is a Novel Positive Immunohistochemical Marker of Epithelioid Mesothelioma to Differentiate It From Lung Adenocarcinoma and/or Squamous Cell Carcinoma. Nakagiri T, Amatya VJ, Kushitani K, Kambara T, Aoe K, Endo I, Miyata Y, Okada M, Takeshima Y. Am J Surg Pathol. 2024 Feb;48(2):140-149
・FOXM1 Promotes Mesothelioma Cell Migration and Invasion via Activation of SMAD Signaling. Endo I, Amatya VJ, Kushitani K, Kambara T, Nakagiri T, Aoe K, Takeshima Y. Anticancer Res. 2023 Sep;43(9):3961-3968.
・ SOX6 Is a Novel Immunohistochemical Marker for Differential Diagnosis of Epithelioid Mesothelioma From Lung Adenocarcinoma. Kambara T, Amatya VJ, Kushitani K, Suzuki R, Fujii Y, Kai Y, Miyata Y, Okada M, Takeshima Y. Am J Surg Pathol. 2020 Sep;44(9):1259-1265.
・ Mucin 21 Is a Novel, Negative Immunohistochemical Marker for Epithelioid Mesothelioma for Its Differentiation from Lung Adenocarcinoma. Kai Y, Amatya VJ, Kushitani K, Kambara T, Suzuki R, Tsutani Y, Miyata Y, Okada M, and Takeshima Y. Histopathology. 2019, 74(4):545-54
・ Mir-182 and Mir-183 Promote Cell Proliferation and Invasion by Targeting Foxo1 in Mesothelioma. Suzuki R, Amatya VJ, Kushitani K, Kai Y, Kambara T, and Takeshima Y. Front Oncol. 2018, 8(446)

【Education】
At the faculty, We are teaching "Pathologic Basis of Disease" including etiology, morphological changes, pathological diagnosis and therapy of diseases by "Tutorial method" and practical training by using "Virtual Slide System". We are also teaching Pathological diagnosis & recent topics of pathology to students at Clinical training. At the post-graduate course, the schemas listed below will be given to each student, for obtaining PhD and also teaching pathological diagnosis of biopsy, surgical specimens and autopsy cases for acquisition of certification of professional pathologist and cyto-pathologist.

【Research】
１．Analysis of biological nature of human cancers, especially lung cancer and mesothelioma, and its application for pathological diagnosis and appropriate therapy
２．Role of microRNAs in mesothelioma and lung cancer.
３．Role of apoptosis related protein and genes in mesothelioma
４．Development of useful antibodies for pathological diagnosis at general hospitals.
５．Molecular epidemiological study of asbestos-related diseases (lung cancers and mesotheliomas)
６．Pathobiological analysis of respiratory organ among former poisonous gas exposures
７．Development of system of pathology education and pathology diagnosis by Virtual slide