Physiology and Biophysics

Prof. Yuichiro Fujiwara

【Research Keyword】
Principles of operation of ion channels, receptors and transporters, Electrophysiology, Structural biology, Intermolecular interaction, Biosensor, Artificial ion channel creation, Channelopathy

【Recent highlights】
Mechanism of functional modification of H+ channels by direct binding of ATP (J Physiol. 2023) and K+ channels by direct binding of phosphoinositides (J Biol Chem. 2022). Structural basis for sugar selectivity of glucose transporter (J Mol Biol. 2022). Discovery and structural analysis of a novel light-driven channel (Nat Struct Mol Biol. 2022). 

Profiles of Faculty and Research Scholars

Undergraduate program: lectures and practical training in "Physiology"
Graduate school: lectures on "Research Methodology" and "Functions of the Human Body", exercises and practical training on "Special Seminar" and "Special Research".

Physiology is the study of functions of the human body. The systematized functions of the human body strongly reflect the properties of its component parts. In our laboratory, we conduct research to understand the human body by exploring the functions of the biomolecules, which are the components of the human body. Our target is the biosensor molecules. Living organisms, including humans, maintain their lives by adapting to the external environment. The cell membrane is the barrier that separates the inside and outside of living organisms, and sensor molecules exist in the membrane. Sensor molecules convert physical and chemical inputs such as voltage, temperature, light, pH, and concentration from the outside world into biological outputs that trigger life activities. We study the sensor mechanisms and energy conversion mechanisms of membrane proteins (ion channels, receptors, and transporters)