Gastroenterological and Transplant Surgery

Prof. Hideki Ohdan

【Research Keyword】
Gastric cancer, Colorectal cancer, Hepatic cancer, Pancreatic cancer, Organ transplant, Cancer immunology, Transplant immunology, Chemotherapy, Minimally invasive surgery, Medical engineering, Hepatitis, Organ preservation, NK cells

【Recent highlights】
We perform minimally invasive and precise robotic-assisted surgery for gastric, colorectal, and liver cancer. We perform laparoscopic sleeve gastrectomy for morbid obesity. As an accredited facility for deceased donor transplantation, we perform renal, pancreatic, and liver transplants. We also perform living donor kidney and liver transplants. We are conducting clinical trials for Type 1 Technology for Regenerative Medicine, "Postoperative immunostimulation therapy using donor-derived activated natural killer (NK) cells in liver transplantation" and Type 2 Technology for Regenerative Medicine, "Peripheral hematopoietic stem cell-derived NK cell transfer therapy to prevent recurrence after liver resection for hepatocellular carcinoma". Utilizing the MRI operating room (SCOT: Smart Cyber Operating Theater), we perform navigation surgery for small liver cancer cases that cannot be recognized by intraoperative ultrasound.

Profiles of Faculty and Research Scholars

We are promoting education in the four specialized gastroenterological field, upper gastrointestinal tract, lower gastrointestinal tract, hepatobiliary pancreatic, and transplant fields. We aim to train excellent researchers and transmit their achievements to home and abroad through graduate school studies with high specialty. We also aim to acquire essential surgical skills and practicalize creative problem-solving through participatory clinical training in medical school. We make efforts to train surgeons and surgical scientists who can feel their patient’s pain and suffering and are excellent in researches, skills, scholarship and characters.

Aim to provide effective and safe medical treatment closely related to clinical practice, we are working on the following studies.
1.Development of methods for immune-monitoring and induction of immune-tolerance
2.Development of immune-regulatory strategies in xenotransplantation
3.Elucidation of mechanism underlying antibody-mediate rejection
4.Elucidation of characteristics of liver-resident immunocytes
5.Development of approaches for immune-therapy against cancer
6.Elucidation of mechanism underlying liver regeneration
7.Development of measures for patient managements after kidney, pancreas and liver transplantation
8.Development of strategies for ameliorating organ ischemia-reperfusion injury
9.Development of approaches for molecular-targeting therapy against gastroenterological cancer
10.Development of procedures gastroenterological surgeries
11.Development of humanized mouse model for investigating gastroenterological cancer
12.Development of devices for less invasive surgeries
13.Genetic and epigenetic analyses in gastroenterological cancer

【Figure explanation】Overview of MRI-Guided liver resection

【Photo explanation】Group photo of department members

【Photo explanation】Photo in the lab