Obstetrics and Gynecology

Prof. Yoshiki Kudo

【Research Keyword】
Placenta, Hypertensive disorders of pregnancy:HDP, Preterm birth, Gynecological tumor, Drug resistance, Transporter

【Recent highlights】
Our recent publications are as follows, “Suppressyn localization and dynamic expression patterns in primary human tissues support a physiologic role in human placentation”(Sugimoto et al, Sci Rep, 2019), “Indoleamine 2,3-dioxygenase and trophoblast invasion in caesarean scar pregnancy: Implications for the aetiopathogenesis of placenta accreta spectrum” (Kudo et al, J Reprod Immunol, 2019), “Regulation of REG4 Expression and Prediction of 5-Fluorouracil Sensitivity by CDX2 in Ovarian Mucinous Carcinoma” (Koh et al, Cancer Genomics Proteomics, 2019)
In 2019, research on “transport mechanism of nicotine and effect on nutrient transport system in placenta” was evaluated, and Dr. Takako Sadakane was awarded excellent presentation award at the 43rd Annual meeting of the Japan society for study of Women’s Nutrition and Metabolism.
In addition, we are now conducting clinical research on "prediction of the onset of preeclampsia using sFlt-1/PlGF ratio" and are collaborating with Dr. Sofia Cerdeira of Oxford University.

Profiles of Faculty and Research Scholars

 Educational content in obstetrics and gynecology is intended to impart an understanding of topics including pregnant and parturient women and the pathology, diagnosis and treatment of gynecological diseases through lectures.
 There is a wide range of content to be learned, focusing on the four areas of perinatal period, gynecologic oncology, reproductive and endocrine, and female health care. Obstetrics imparts correct knowledge particularly regarding pregnancy and childbirth, which are major events in women’s lives, and teaches about anomalies during pregnancy and labor. Gynecology teaches about topics including anatomy, the endocrine environment, and neoplastic lesions.
 In clinical training, medical students will consider interviews with pregnant women and patients with gynecological diseases and necessary medical examinations through experiencing ward medical treatment, outpatient treatment, and ward conferences. Based on the results, they can learn concretely the process of diagnosing the disease and deciding the treatment method and the appropriate explanation. They can participate in surgery to understand the anatomy in the pelvis and learn the basic procedures of surgery.

Perinatal department
1.The study of trophoblast development
2.Research into the relationship between inflammation and pre-term labor
3.Transport mechanism of nicotine and effect on nutrient transport system in placenta
4.Dynamics of sFlt-1/PlGF in pregnancy physiology and pathology

Gynecology department
1. Research into transporter expression and drug resistance in ovarian cancer
2. Analysis of amino acid transporter and development of novel chemotherapy in ovarian cancer
3. miRNA analysis for an improvement of cytology of endometrium as endometrial cancer screening

【Photo explanation】 Laboratory