Obstetrics and Gynecology

The original website is here.

Prof. Yoshiki Kudo

【Research Keyword】
Placenta, Hypertensive disorders of pregnancy: HDP, Preterm birth, Periodontal pathogen, Gynecological tumor, Drug resistance, Transporter, Artificial Intelligence: AI

【Recent highlights】
Our recent publications are as follows, “Progesterone Suppresses Uterine Contraction by Reducing Odontogenic Porphyromonas gingivalis Induced Chronic Inflammation in Mice” (Teraoka et al, Biomolecules, 2022), “Selective Inhibition of L-type Amino Acid Transporter 1 Suppresses Cell Proliferation in Ovarian Clear Cell Carcinoma” (Sekine et al, Anticancer Research, 2023), “Contorolling Trophoblast Cell Fusion in the Human Placenta – Transcriptional Regulation of Suppressyn, an Endogenous Inhibitor of Syncytin-1”(Sugimoto et al, Biomolecules, 2023), “The Role of the Placental Enzyme Indoleamine 2,3-Dioxygenase in Normal and Abnormal Human Pregnancy”(Kudo et al, Int J Mol Sci, 2024).
In addition, we are developing a new treatment strategy targeting amino acid transporters for ovarian clear cell carcinoma, and conducting joint research with the Program of Basic Biology, Graduate School of Integrated Sciences for Life, the Cellular and Molecular Biology, Graduate School of Pharmaceutical Sciences, and the department of Radiation Oncology, Graduate School of Biomedical and Health Sciences. We are working on “building a new diagnosis and treatment effect prediction system using artificial intelligence (AI) that integrates biological analysis and medical images for gynecological cancer”.
Furthermore, by applying organoid technology, we succeeded in reproducing the ovarian cancer by introducing various genes into the epithelium of the fallopian tube in mice, and are currently preparing to submit the results.
Recent clinical research are as follows: a pilot study aimed at sentinel node navigation surgery and the study for uterus transplantation as a functional reconstruction technique.
Profiles of Faculty and Research Scholars

【Education】
Educational content in obstetrics and gynecology is intended to impart an understanding of topics including pregnant and parturient women and the pathology, diagnosis and treatment of gynecological diseases through lectures.
There is a wide range of content to be learned, focusing on the four areas of perinatal period, gynecologic oncology, reproductive and endocrine, and female health care. Obstetrics imparts correct knowledge particularly regarding pregnancy and childbirth, which are major events in women’s lives, and teaches about anomalies during pregnancy and labor. Gynecology teaches about topics including anatomy, the endocrine environment, and neoplastic lesions.
In clinical training, medical students will consider interviews with pregnant women and patients with gynecological diseases and necessary medical examinations through experiencing ward medical treatment, outpatient treatment, and ward conferences. Based on the results, they can learn concretely the process of diagnosing the disease and deciding the treatment method and the appropriate explanation. They can participate in surgery to understand the anatomy in the pelvis and learn the basic procedures of surgery.

【Research】
Perinatal department
1.The study of trophoblast development
2.Research into the relationship between inflammation and pre-term labor
3.Transport mechanism of nicotine and effect on nutrient transport system in placenta
4.Dynamics of sFlt-1/PlGF in pregnancy physiology and pathology

Gynecology department
1. Research into transporter expression and drug resistance in ovarian cancer
2. Analysis of amino acid transporter and development of novel chemotherapy in ovarian cancer
3. miRNA analysis for an improvement of cytology of endometrium as endometrial cancer screening
4. Building a new diagnosis and treatment effect prediction system using artificial intelligence (AI) that integrates biological analysis and medical images for gynecological cancer

【Photo explanation】Laboratory

Site Policy Privacy Policy