Urology

Prof. Akio Matsubara

【Research Keyword】
Prostate cancer, bladder cancer, renal cell carcinoma, novel diagnostics and therapeutics, penis regeneration, bladder regeneration

【Recent highlights】
Since the first robot-assisted total prostatectomy in Chugoku–Shikoku District in 2010, our department has become one of the leading Japanese medical institutions offering robot-assisted surgeries. In 2014 and 2015, our department had the fourth highest volume in Japan for urologic surgeries, with 685 radical prostatectomies, 108 partial nephrectomies, and 14 radical cystectomies conducted to date. Based on our expertise and achievements, our department has been designated as the fifth observation site in Japan for robot-assisted surgeries by Intuitive Surgical G.K., Tokyo. We frequently host visits from surgeons and health care workers. Our department excels in creative and innovative research. The number of adoptions for scientific research grants from the Ministry of Education, Culture, Sports, Science and Technology, and other external funds were 13+4 in 2017, 11+6 in 2018, 11+4 in 2019, respectively. Many of our studies have been accepted for presentations at the annual meetings of the European Association of Urology and the American Urological Association (mean 7.3/year since 2014). Seven presentations have received best poster awards, including one presentation that won the first prize.

Profiles of Faculty and Research Scholars

【Education】
The lectures give a general introduction to medical conditions, examinations, treatments, and surgical procedures in urology. Specific topics include genitourinary cancers, urinary tract infections, urolithiasis, genitourinary trauma, male infertility, sex differentiation disorders, development and anomalies of the urogenital system, and voiding dysfunction. Clinical training provides medical students with an opportunity to learn in a supervised clinical setting, not merely observe experienced physicians. During the fifth-year clerkship, students will have hands-on experience with cystoscopy and other urologic examinations. In the sixth-year advanced program, students will have the opportunity to learn one-on-one from instructors at the “sub-intern” level. More specifically, students will discuss treatment approaches with the attending physician, participate in and make presentations at case conferences, and take part in informed consent procedures. They will also participate in laparoscopic surgeries as a scopist (camera assistant) and as an assistant surgeon responsible for suturing and other skin closure procedures in open surgeries. In the fourth-year training program, students will engage in basic research projects in urologic oncology to become familiar with scientific methodologies.

【Research】
Development of novel serum biomarkers and therapeutic methods for castration-resistant prostate cancer
・Regulation of prolyl isomerization in prostate cancer and its therapeutic application
・Role of endocrine fibroblast growth factors in prostate cancer progression
・Expression and function of transcribed ultraconserved non-coding RNAs in prostate cancer
・Development of novel diagnostic markers and therapeutic methods for bladder cancer
・Effects of molecularly targeted drugs on the tumor interstitium
・Bladder regeneration using magnetic nanoparticle–labeled mesenchymal stem cells
・Hematopoietic stem cell transplant for the treatment of erectile dysfunction

【Photo explanation】 a student doctor attending laparoscopic nephrectomy as a scopist.


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