【Research Keyword】
Chronic kidney disease (CKD), Hemodialysis, Peritoneal dialysis, Epigenetics, Senescence, Mesenchymal stem cells, Salt-sensitive hypertension
【Recent highlights】
Recently, we have demonstrated that inhibition of H3K4 histone methyltransferase (SET7/9) and H3K9 histone methyltransferase (G9a) ameliorates renal fibrosis. As a result, we have clarified the association between transcriptional activities through histone modification and the progression of renal fibrosis. We conduct basic research to answer clinical questions with a consequent focus on drug discovery.