【Major Papers of the Laboratory】
・Shimoda H, Doi S, Nakashima A, Sasaki K, T Doi, Arihiro K, Masaki T. Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16INK4a. Kidney Int. 2019 Nov;96(5):1162-1175
・Irifuku T, Doi S, Sasaki K, Doi T, Nakashima A, Ueno T, Yamada K, Arihiro K, Kohno N, Masaki T. Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression. Kidney Int. 2016 Jan;89(1):147-157.
・Sasaki K, Doi S, Nakashima A, Irifuku T, Yamada K, Kokoroishi K, Ueno T, Doi T, Hida E, Arihiro K, Kohno N, Masaki T: Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis. J Am Soc Nephrol. 2016 Jan;27(1) 203-215.
・Ueno T, Nakashima A, Doi S, Kawamoto T, Honda K, Yokoyama Y, Doi T, Higashi Y, Yorioka N, Kato Y, Kohno N, Masaki T: Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-β1 signaling. Kidney Int. 2013 Aug;84(2):297-307.

【Education】
We are responsible for treating various renal diseases; including primary glomerular disease, tubulointerstitial disorders, and systemic renal diseases such as hypertension, diabetes, connective tissue disease, and blood disorders. We also treat acute and chronic renal failure that often requires hemodialysis or peritoneal dialysis. The purpose of education is to teach not only a high degree of specialization, but also general internal medicine as nephrology incorporates many factors related to other treatment departments.

【Research】
1. Research on therapeutic mechanisms targeting renal and peritoneal fibrosis associated with epigenetics, cell death, and senescence.
2. Research on the pathogenesis of hypertension, with a particular focus on salt-sensitive hypertension and sodium channel signaling.
3. Research on the therapeutic effect of mesenchymal stem cells against the progression of renal fibrosis.
4. Clinical research on cardiovascular complications and prognosis in hemodialysis patients.
5. Clinical research on risk factors for the onset of chronic kidney disease.
6. Clinical research on risk factors for renal failure using kidney biopsy pathology specimens.