【Research Keyword】
Multidrug resistance, Antiseptic resistance, Biosynthesis of antibiotics, Microbial useful enzymes for the industrial application
【Recent highlights】
In 2015, we identified the target of 6,6’-dihydroxythiobinupharidine in Staphylococcus aureus. Also, we reported about the construction of higher production system for antituberculous drug in Escherichia coli. In 2016, we reported about a novel factor for antiseptic resistance in Serratia marcescens.
【Education】
・Microbiology：Microorganisms (bacteria, viruses, fungi) which cause infectious diseases
・Biochemistry I：DNA replication, Transcription, Translation
・Biochemistry II：Protein and amino acids
・Antibiotics and Drug resistance: Action mechanism of antimicrobial agents
・Genetic Engineering：Technique of gene manipulation
・Experiments of Microbial Chemistry：Fundamental Technique for Microbiology
【Research】
１．Screening of seed compounds which has antimicrobial activity and Identification of its action target
２．Study of antiseptic resistance mechanism
３．Study of emergence of multidrug resistant bacteria
４．Study of tolerance for Na+ in marine bacteria
５．Structural study of microbial useful enzymes for the industrial application and target proteins for the drug development
６．Functional analysis of antibiotic biosynthetic genes from actinomycetes and its application for the production of useful compounds
【Figure explanation】 Action mechanism of 6,6’-dihydroxythiobinupharidine in Staphylococcus aureus
【Figure explanation】 Action mechanism of riccardin C derivatives in Staphylococcus aureus
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