Japanese

Pharmaceutical Services

Prof. Hiroaki Matsuo

【Research Keyword】
proper use of drugs, therapeutic drug monitoring, extravasation, food allergy, drug allergy, drug information, safety of medicine

【Recent highlights】
We had shown that increased serum levels of ingested allergen were required to elicit allergic reactions in provocation tests in patients with food-dependent exercise-induced anaphylaxis and nonsteroidal anti-inflammatory drugs such as aspirin increased the absorption of allergens in human and rats. These results indicate that intake of drugs that increases absorption of allergen from intestine enhances allergic reactions and sensitization. We studied how the drugs increase the absorption of allergens with high molecular weight and development of food allergy using rat model of food allergy. As a result, aspirin augmented allergen absorption via the paracellular pathway and sodium cromoglycate and prostaglandin prevent the increase in allergen absorption.

Profiles of Faculty and Research Scholars

【Education】
　In order to participate drug therapy independently, pharmacists should have the ability to identify challenges, gather information, make decisions, take action, and think logically in addition to knowledge of pharmaceutical science. We provide lectures, “Clinical Pharmacy” and “Clinical Medicine and Pharmacotherapy”, and 11 weeks-practical training in hospital pharmacy for undergraduates. In the practical training, we aim to foster leading pharmacists who can play a key role in social welfare, health and medical service, and education through clinical experiences, group discussions and presentation opportunities regarding pharmaceutical services and clinical cases. In education for graduate students, research leading to proper use of drugs have been conducted to contribute the development of advanced medical care and pharmacotherapy.

【Research】
・Proper use of anticancer agent by therapeutic drug monitoring
・Influences of metabolite of antiparkinson drugs on short-term memory
・Treatment for injury due to extravasation of thiopental and propofol
・Pharmacokinetics and pharmacodynamics of pregabalin
・Effects of drugs on insulin secretion from pancreatic beta-cells
・Effects of drugs on development of food allergy
・Identification of the causative drug in patient with drug allergy
・Proper use of medicine based on drug information

【Photo explanation】Determination of drug dosage by therapeutic drug monitoring（TDM）