proper use of drugs, therapeutic drug monitoring, extravasation, food allergy, drug allergy, drug information, safety of medicine
We had shown that increased serum levels of ingested allergen were required to elicit allergic reactions in provocation tests in patients with food-dependent exercise-induced anaphylaxis and nonsteroidal anti-inflammatory drugs such as aspirin increased the absorption of allergens in human and rats. These results indicate that intake of drugs that increases absorption of allergen from intestine enhances allergic reactions and sensitization. We studied how the drugs increase the absorption of allergens with high molecular weight and development of food allergy using rat model of food allergy. As a result, aspirin augmented allergen absorption via the paracellular pathway and sodium cromoglycate and prostaglandin prevent the increase in allergen absorption.