【Education】
Educational content in obstetrics and gynecology is intended to impart an understanding of topics including pregnant and parturient women and the pathology, diagnosis and treatment of gynecological diseases through lectures.
There is a wide range of content to be learned, focusing on the four areas of perinatal period, gynecologic oncology, reproductive and endocrine, and female health care. Obstetrics imparts correct knowledge particularly regarding pregnancy and childbirth, which are major events in women’s lives, and teaches about anomalies during pregnancy and labor. Gynecology teaches about topics including anatomy, the endocrine environment, and neoplastic lesions.
In clinical training, medical students will consider interviews with pregnant women and patients with gynecological diseases and necessary medical examinations through experiencing ward medical treatment, outpatient treatment, and ward conferences. Based on the results, they can learn concretely the process of diagnosing the disease and deciding the treatment method and the appropriate explanation. They can participate in surgery to understand the anatomy in the pelvis and learn the basic procedures of surgery.

【Research】
Perinatal department
1.The study of trophoblast development
2.Research into the relationship between inflammation and pre-term labor
3.Transport mechanism of nicotine and effect on nutrient transport system in placenta
4.Dynamics of sFlt-1/PlGF in pregnancy physiology and pathology

Gynecology department
1. Research into transporter expression and drug resistance in ovarian cancer
2. Analysis of amino acid transporter and development of novel chemotherapy in ovarian cancer
3. miRNA analysis for an improvement of cytology of endometrium as endometrial cancer screening
4. Building a new diagnosis and treatment effect prediction system using artificial intelligence (AI) that integrates biological analysis and medical images for gynecological cancer

【Major Papers of the Laboratory】
・Predictive Accuracy of sFlt-1/PlGF ratio for Preeclampsia and Adverse Outcomes: Prospevtive, Multicenter Including Primary, Secondary, and Tertiary Care Institutions, Ovservational Study in Japan. Yamazaki T, Cerdeira AS, Teraoka Y, Oomori Y, Mukai Y, Sugimoto J, Koh I, Banno K, Vatish M, Kudo Y. Hypertens Res. 2025. In press
・Usefulness of video explanation for informed consent in gynecologic surgery. Suzui R, Taki M, Yamanoi K, Kitamura S, Sunada M, Okunomiya A, Kitawaki Y, Murakami R, Yamaguchi K, Horie A, Hamanishi J, Mandai M. Int J Gynaecol Obstet. 2025 Jun 12. doi: 10.1002/ijgo.70248. Online ahead of print. PMID: 40504086
・Awareness and attitude toward cardio-oncology among Japanese gynecologic oncologists in managing patients with endometrial cancer: The Japanese Gynecologic Oncology Group (JGOG) questionnaire surveys. Kobayashi Y, Asai-Sato M, Kuji S, Sakai H, Yamaguchi K, Suzuki N, Yoshida Y. J Obstet Gynaecol Res. 2025 Feb;51(2):e16225. doi: 10.1111/jog.16225. PMID: 39908989
・Prognostic significance of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio in uterine carcinosarcoma. Sakurai A, Yamaguchi K, Ishida K, Horikawa N, Kawai E, Kotani Y, Yoshida T, Kishimoto N, Tatsumi K, Okudate M, Iemura Y, Taga Y, Aki M, Ando Y, Yanai A, Yamanoi K, Taki M, Murakami R, Hamanishi J, Mandai M. Int J Clin Oncol. 2025 Mar;30(3):570-583. doi: 10.1007/s10147-024-02687-w. Epub 2025 Jan 8. PMID: 39779654 
・Changes in Physical Activity Across Cancer Diagnosis and Treatment Based on Smartphone Step Count Data Linked to a Japanese Claims Database: Retrospective Cohort Study. Inayama Y, Yamaguchi K, Mizuno K, Tanaka-Mizuno S, Koike A, Higashiyama N, Taki M, Yamanoi K, Murakami R, Hamanishi J, Yoshida S, Mandai M, Kawakami K. JMIR Cancer. 2025 Jan 20;11:e58093. doi: 10.2196/58093. PMID: 39726139
・Proposal for Managing Cancer-Related Insomnia: A Systematic Literature Review of Associated Factors and a Narrative Review of Treatment. Saeki Y, Sumi Y, Ozaki Y, Hosonaga M, Kenmotsu Y, Onoe T, Yamaguchi K, Matsumoto Y. Cancer Med. 2024 Nov;13(22):e70365. doi: 10.1002/cam4.70365. PMID: 39584650
・Electronic patient-reported outcomes as digital therapeutics for patients with cancer: a narrative review of current practices and future directions. Yamaguchi K, Higashiyama N, Umemiya M, Inayama Y, Koike A, Ueda A, Mizuno R, Taki M, Yamanoi K, Murakami R, Hamanishi J, Mandai M. Int J Clin Oncol. 2025 Jan;30(1):1-16. doi: 10.1007/s10147-024-02651-8. Epub 2024 Nov 16. PMID: 39549219
・YAP1 Suppression by ZDHHC7 Is Associated with Ferroptosis Resistance and Poor Prognosis in Ovarian Clear Cell Carcinoma. Furutake Y, Yamaguchi K, Yamanoi K, Kitamura S, Takamatsu S, Taki M, Ukita M, Hosoe Y, Murakami R, Abiko K, Horie A, Hamanishi J, Baba T, Matsumura N, Mandai M. Mol Cancer Ther. 2024 Nov 4;23(11):1652-1665. doi: 10.1158/1535-7163.MCT-24-0145. PMID: 38958503
・Mixed gonadal dysgenesis with gonadoblastoma diagnosed by prophylactic laparoscopic gonadectomy: A case report. Uyama T, Koh I, Komoshita T, Matsushima A, Ohara R, Nomura A, Enokizono Y, Sato Y, Nakamoto K, Morioka H, Oomori Y, Teraoka Y, Nosaka S, Tomono K, Sekine M, Yamazaki T, Mukai Y, Banno K, Kurahashi H, Kudo Y.  Exp Ther Med. 2024 Jul 9;28(3):358. doi: 10.3892/etm.2024.12647. PMID: 39071906; PMCID: PMC11273338.
・High-Grade Endometrial Cancer: Molecular Subtypes, Current Challenges, and Treatment Options. Matoba Y, Devins KM, Milane L, Manning WB, Mazina V, Yeku OO, Rueda BR. Reprod Sci. 2024 Sep;31(9):2541-2559.
・Targeting Galectin 3 illuminates its contributions to the pathology of uterine serous carcinoma. Matoba Y, Zarrella DT, Pooladanda V, Azimi Mohammadabadi M, Kim E, Kumar S, Xu M, Qin X, Ray LJ, Devins KM, Kumar R, Kononenko A, Eisenhauer E, Veillard IE, Yamagami W, Hill SJ, Sarosiek KA, Yeku OO, Spriggs DR, Rueda BR. Br J Cancer. 2024 May;130(9):1463-1476.
・Controlling Trophoblast Cell Fusion in the Human Placenta-Transcriptional Regulation of Suppressyn, an Endogenous Inhibitor of Syncytin-1. Sugimoto J, Schust DJ, Sugimoto M, Jinno Y, Kudo Y. Biomolecules. 2023 Nov 7;13(11):1627. doi:10.3390/biom13111627. PMID: 38002309; PMCID: PMC10668956. 
・Real-world practice of estrogen and progestogen prescriptions in menopausal women in Japan: A descriptive study using a Japanese claims database. Inayama Y, Mizuno K, Egawa M, Yamaguchi K, Hamanishi J, Takeuchi M, Mandai M, Kawakami K. J Obstet Gynaecol Res. 2023 Dec;49(12):2952-2961. doi: 10.1111/jog.15795. Epub 2023 Sep 26. PMID: 37752731
・Hormone replacement therapy and cancer risks in perimenopausal women: A retrospective cohort study using a Japanese claims database. Inayama Y, Mizuno K, Yamaguchi K, Hamanishi J, Takeuchi M, Egawa M, Mandai M, Kawakami K. J Obstet Gynaecol Res. 2023 Jul;49(7):1805-1814. doi: 10.1111/jog.15653. Epub 2023 Apr 8. PMID: 37029559 
・ATM mutation in aggressive uterine adenosarcoma in which systemic chemotherapies had remarkable effects. Koyama M, Yamaguchi K, Chigusa Y, Yamanoi K, Taki M, Sunada M, Horie A, Hamanishi J, Minamiguchi S, Mandai M. Int Cancer Conf J. 2023 Jan 12;12(2):120-125. doi: 10.1007/s13691-022-00591-6. eCollection 2023 Apr. PMID: 36896195 
・Real-world practice of estrogen therapy after surgery for endometrial cancer: a descriptive study using a Japanese claims database. Inayama Y, Mizuno K, Yamaguchi K, Hamanishi J, Takeuchi M, Egawa M, Mandai M, Kawakami K. Int J Clin Oncol. 2023 Mar;28(3):445-453. doi: 10.1007/s10147-022-02289-4. Epub 2023 Jan 4. PMID: 36598591