【Major Papers of the Laboratory】
・Aizawa, H., Matsumata, M., Oishi, L. A. N., Nishimura, F., Kasaragod, D. K., Yao, X., Tan, W., Aida, T., & Tanaka, K. (2025). Potassium release from the habenular astrocytes induces depressive-like behaviors in mice. Glia, 73(4), 759–772. https://doi.org/10.1002/glia.24647
・Handa, T., Zhang, Q., Ma, Z., & Aizawa, H. (2025). Cell type-specific contribution to the initiation of cortical spreading depolarization in the mouse. Biochemical and biophysical research communications, 751, 151428. https://doi.org/10.1016/j.bbrc.2025.151428
・Ito, H., Nozaki, K., Sakimura, K., Abe, M., Yamawaki, S., & Aizawa, H. (2021). Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 46(2), 442–454. https://doi.org/10.1038/s41386-020-00843-0
・Cui, W., Aida, T., Ito, H., Kobayashi, K., Wada, Y., Kato, S., Nakano, T., Zhu, M., Isa, K., Kobayashi, K., Isa, T., Tanaka, K., & Aizawa, H. (2020). Dopaminergic Signaling in the Nucleus Accumbens Modulates Stress-Coping Strategies during Inescapable Stress. The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(38), 7241–7254. https://doi.org/10.1523/JNEUROSCI.0444-20.2020 
・Aizawa, H., Sun, W., Sugiyama, K., Itou, Y., Aida, T., Cui, W., Toyoda, S., Terai, H., Yanagisawa, M., & Tanaka, K. (2020). Glial glutamate transporter GLT-1 determines susceptibility to spreading depression in the mouse cerebral cortex. Glia, 68(12), 2631–2642. https://doi.org/10.1002/glia.23874

【Education】
With the international background in Hiroshima, our lab encourages the students and researcher to develop their careers by scholarship and grants. Indeed, our lab members from a variety of countries all over the world weekly hold the meeting for the progress report and journal club. We also discuss the textbook to help the international students to understand the basics in neuroscience, molecular biology and data science periodically.

【Research】
Our lab works for the animal models of the neurological and psychiatric disorders such as depression, migraine and stroke. On one hand, we use mice to fill the gap between cellular activity and behavioral alterations upon exposure to the stress by examining neural network activity. On the other hand, we use zebrafish to image and manipulate the cellular activity to reveal mechanism underlying pathological neural excitation associated with headache, stroke and traumatic brain injury.