日　時：2006年10月11日（水）16：10〜17：40



場　所：理学部E211教室



講演題目：

　Understanding Molecular Structures of Polymers and Biomolecules at Interfaces



講 演 者：Dr. Zhan CHEN

　(Associate Professor of Chemistry, Applied Physics and Macromolecular Science and Engineering, Associate Faculty of Biophysics Department of Chemistry, University of Michigan)



概 要：

Molecular structures of polymers and biological molecules such as proteins and peptides play important roles in biocompatibility, anti-biofouling control, adhesion, membrane protein function, and anti-microbial peptide behavior. Sum frequency generation (SFG) vibrational spectroscopy has been applied to investigate molecular structures of polymers, proteins, and peptides at the solid/liquid interface in situ in real time. SFG studies on polymer materials reveal molecular level details regarding polymer surface restructuring in water and polymer adhesion. SFG results of biological molecules demonstrate that C-H stretching and amide signals can elucidate structures of hydrophobic side chains and secondary structures of interfacial peptides and proteins. Several supplemental techniques including ATR-FTIR, QCM, four-wave mixing vibrational spectroscopy, and contact angle goniometry have been used in the research to substantiate the SFG results. Experimental results have been compared to those obtained from theoretical simulations. Lipid bilayers have been used as models for cell membranes to elucidate molecular interactions between cell membranes and antimicrobial peptides as well as some simple antibiotic compounds. This research demonstrates that SFG is a powerful technique which can elucidate molecular structures of polymers, proteins, and peptides at interfaces in situ.



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