Oral and Maxillofacial Pathobiology

Prof. Mutsumi Miyauchi

【Research Keyword】
Oral cancer, molecular pathology, periodontal disease, tissue regeneration, salivary gland tumor, odontogenic tumor and histopathological diagnosis

【Recent highlights】
・We determined ameloblastin, an enamel matrix protein, is related to bone formation and inhibition of proliferation and differentiation of osteosarcoma.
・We found the role of lactoferrin in periodontitis and rheumatoid arthritis as an agent for prevention and therapy.
・We determined the role of VEGF-Flt-1 signaling in bone invasion in oral cancer.
・We determined periodontal pathogens could reach liver via blood circulation and cause progression of liver fibrosis through TGF-beta and Galectin-3 production. Elimination of periodontal pathogen by antibiotic reduced liver inflammation and fibrosis.
・We determined dental infection with periodontal pathogens induced preterm birth through Galectin-3.
・We have won various prizes during the past 5 years including five by staff members, 9 by graduate students and 15 by undergraduate students who are members of our laboratory.

Profiles of Faculty and Research Scholars

Pathology is the study of the causes and mechanisms of diseases, and aims to set standards for diagnosis to support the development of novel therapies. Our lectures provide a study of oral diseases and general diseases and their relationship to clinical application, which permit students to have a solid basis of dentistry.

Our research activities are:

  1. Using genetic analysis in abnormal proliferation and metastasis of oral cancer, we focus on developing genetic diagnosis and therapy.
  2. Studying the mechanism of destruction and regeneration of periodontal tissues, we focus on developing novel periodontal diagnosis and therapy.
  3. Determining the cellular differentiation of odontogenic and salivary gland tumors, we focus on setting criteria of pathological diagnosis of the tumors.

【Photo explanation】 Detection of periodontal pathogen (→) and P.g. specific gene in placenta of P.g. odontogenic infection mouse model showing preterm birth
(Ao Min et al. PLoS One. 2015 Aug 31;10(8):e0137249. )


【Photo explanation】 The inhibitory effect of lactoferrin on tumor growth and bone invasion of oral squamous cell carcinoma