Oral and Maxillofacial Surgery

Prof. Tomonao Aikawa

【Research Keyword】
Gnathodiaphyseal dysplasia, cemento-osseous dysplasia, responsible gene, oral cancer, invasion and metastasis, epithelial to mesenchymal transition, oral mucosal diseases, novel biomaterials, regenerative medicine for jaw bone.

【Recent highlights】
We study regenerative medicine of the jaw bone using novel interconnected porous hydroxyapatite ceramics (IP-CHA) as basic scaffold material for osteoblasts.

We lecture in the various fundamental knowledge of disease, diagnostics and therapeutics in the fields of oral and maxillofacial surgery. We perform basic practices such as several blood tests, physiological examination and technique, blood sampling・injection, counter-measures for infection・cleaning operation, and Basic Life Support (BLS). We conduct model procedures using appliances for tooth extraction, cyst extirpation, incision/suture, and tooth ligation. Students learn individually diagnostic methods or therapeutic policies in response to a variety of presented cases; we have small group tutorial classes; and report our findings preparing slides and manuscripts for presentations at academic meetings. Further in the clinical course, we perform embedment operations using real implants and create splints for temporomandibular arthrosis.
And in clinical practice, students learn medical interviews, various examinations, medication, perioperative management and operation for patients having several diseases at outpatient area, hospital ward or operation room.

We research genomic oral disease, biological characteristics and therapies for various oral tumors, and their molecular biology relating to invasion and metastasis of oral cancer and cell biology regarding intractable lesions of mucous membrane of the mouth. We are also involved in developing new biomaterials for dental implants and chronic mandibular osteomyelitis.

【Photo explanation】 Invasiveness in p63 knockdown in oral squamous cell carcinoma (OSCC) cells
OSCC is a common malignant tumor of the oral cancer. The poor prognosis of OSCC is caused by its local invasion and distant metastasis. p63 play a pivotal role in the regulation of invasion capacity of OSCC cells. We found that p63 knockdown cells exhibited increased invasiveness in in vitro three-dimensional culture.