【Major Papers of the Laboratory】
・Yamamoto T, Yoshida M, Koyama Y, Mulpuri Y, Imado E, Oue K, Doi M, Shimizu Y, Kishimoto N, Hanamoto H, Seo K. Early prevention of carrageenan-induced peripheral/spinal inflammation suppresses microglial hyperreactivity in the trigeminal spinal subnucleus caudalis and alleviates chronic facial nociception. Heliyon. 2025 Jan 7;11(2):e41602.
・Sasaki U, Irifune M, Kochi T, Mukai T, Nakamura Y, Imado E, Oda A, Kamio H, Imamura S, Oue K, Morioka N, Ago Y. Ketamine-induced pica behavior as nausea and vomiting involves dopamine and serotonin receptor activation in the area postrema of rats: A comparison with etomidate and pentobarbital. Eur J Pharmacol. 2025 Oct 15;1005:178068.
・Takahashi T, Yoshida M, Ito N, Koizumi K, Kamio H, Oda A, Oue K, Doi M, Shimizu Y. Anesthetic Management for an Elderly Patient With Severe Bronchiectasis. Anesth Prog. 2025 Mar 12;72(1):33-36.
・Shimizu Y, Irifune M, Takahashi T, Oda A, Kamio H, Imamura S, Sasaki U, Imado E, Okada Y, Ago Y, Morita K, Sakai N. Nitrous oxide increases peripheral blood flow and decreases plasma adrenaline and noradrenaline concentrations in human volunteers: An in vivo nonrandomized clinical and in vitro chromaffin cell culture study. Eur J Pharmacol. 2025 Sep 15;1003:177899.
・Kamio H, Okabe K, Honda M, Kuroda K, Tsuchiya S. Knockdown of decorin in human bone marrow mesenchymal stem cells suppresses proteoglycan layer formation and establishes a pro-inflammatory environment on titanium oxide surfaces. J Mater Sci Mater Med. 2025 Jan 7;36(1):5. Shimizu Y, Takahashi T, Oda A, Imamura S, Imado E, Sasaki U, Kamio H, Suyama M, Uetsuki R, Ohshimo S, Shime N, Hanamoto H. Development of a Pharyngeal Residue Level Assessment Index Using Artificial Intelligence (AI) Acoustic Analysis: A Study Protocol. Cureus. 2025 Feb 1;17(2):e78358.

【Education】
School of Dentistry
Through lectures and practical training in dental anesthesiology, students acquire basic knowledge and skills in areas such as local anesthesia, intravenous sedation, general anesthesia, and emergency treatment. They also learn the basics of anesthesiology and perioperative management, and develop their general management skills. In addition, they are educated in the pathophysiology, diagnosis, and treatment of orofacial pain in dental treatment, and develop a good understanding of pain mechanisms and pain management methods.

Graduate School
Students deepen their understanding of advanced dental anesthesia management, sedation and general anesthesia, and learn research methods to develop their academic abilities to contribute to the development of dental anesthesia. In particular, we are promoting a wide range of research on dental anesthesia, focusing on clinical research related to sedation and monitoring, elucidation of the pathogenesis of orofacial pain, and basic research on the relationship between obesity and periodontal disease. Through this, we aim to contribute to improving the quality of perioperative management and elucidating the relationship between general health and dental diseases. In addition, we are also conducting research into multidimensional pain management, including pharmacological therapy and psychological approaches.

【Research】
1 Non-contact respiration and heart rate monitoring on the dental chair
2 Development of an AI-based acoustic analysis system Development of safe intravenous sedation with remimazolam
3 Development of safe intravenous sedation with remimazolam
4 The elucidation of the developing chronic pain in orofacial region
5 Research on the pathogenesis of Burning Mouth Syndrome (glossodynia)
6 Mechanisms of exacerbation of cognitive dysfunction by oral infections in obese conditions
7 Functional Analysis of SNARE Proteins Involved in Membrane Fusion