HomeResearch
Our research aims to investigate the physiological mechanisms involved in safe and efficient animal production. Current studies focus on the endocrinological and immunological functions of the reproductive and digestive organs in animals and poultry.
1) Studies on the innate immune functions in male and female reproductive organs and digestive tract that play roles in host defense and reproduction in poultry (Yoshimura, Y.)
2) Prevention and treatment of mastitis by investigation of mammary innate immune system in cow and goat. Effect of colostrum on immune system and nutrient status of cow. (Isobe, N.)
3) Regulation of immune function in reproductive and intestinal mucosa in poultry. Health promotion by probiotics. Relationship between egg formation and immune system. (Nii, T.)
Keywords
Antimicrobial peptide, Probiotics, Hormone, Egg laying, Digestive organ,Mammary gland
Antimicrobial peptide (βdefensin) in hen oviduct
MHC II positive cells in hen oviduct
Recent Publications
Terada T, Nii T, Isobe N, Yoshimura Y (2018) Changes in the expression of avian β-defensin (AvBDs) and proinflammatory cytokines and localization of AvBD2 in the intestine of broiler embryos and chicks during their growth. Journal of Poultry Science (in press)
Kang Y , Nii T, Isobe N, Yoshimura Y (2018) Effects of TLR ligands on the expression of cytokines and possible role of NFκB in its process in the theca of chicken follicles. Journal of Poultry Science (in press)
Matsukawa S, Ueno K, Sugino T, Yoshimura Y, Isobe N (2018) Effects of colostrum whey on immune function in the digestive tract of goats. Animal Science Journal (in press)
Elgawish RA, Ogata Y, Hidaka T, Nii T, Yoshimura Y, Isobe N (2018) Changes in plasma concentrations of S100A7 and S100A8 in dairy cows during pregnancy. Reproduction in Domestic Animals (in press)
Elhamouly M, Terada T, Nii T, Isobe N, Yoshimura Y (2018) Innate antiviral immune response against infectious bronchitis virus and involvement of prostaglandin E2 in the uterine mucosa of laying hens. Theriogenology 110: 122-129
Nii T, Isobe N, Yoshimura Y (2018) Effects of interleukin-1β and -6 on the expression of ion transporters for mineralization of eggshell in cultured uterine mucosal tissue of hen. Journal of Poultry Science (in press)
Shinozuka Y, Kawai K, Sato R, Higashitani A, Hamamoto Y, Okita M, Isobe N (2018) Blood ionized calcium levels and acute-phase blood glucose kinetics in goats after intramammary infusion of lipopolysaccharide. The Journal of Veterinary Medical Science 80(2) 242-246
Huang A, Isobe N, Yoshimura Y (2017) Changes in localization and density of CD63-positive exosome-like substances in the hen oviduct with artificial insemination and their effect on sperm viability. Theriogenology 101: 135-143
Kuwahara K, Yoshimura Y, Isobe N (2017) Effect of steroid hormones on the innate immune response induced by Staphylococcus aureus in the goat mammary gland. Reproduction in Domestic Animals 52: 579-584
Nii T, Isobe N, Yoshimura Y (2015) The effect of estrogen on the early cytotoxic response to IB virus infection in hen oviduct. Veterinary Immunology and Immunopathology 164(1-2): 56-66
Nii T, Isobe N, Yoshimura Y (2014) Effects of avian infectious bronchitis virus antigen on eggshell formation and immunoreaction in hen oviduct. Theriogenology 81(8), 1129-1138
Nii T, Isobe N, Yoshimura Y (2013) Effects of repeated lipopolysaccharide stimulation on the development of antigen-presenting cells and T cells pool in hen vagina. Journal of Poultry Science 50(1), 83-89
