Department of Oral and Maxillofacial Surgery

Introduction of departments

The Oral and Maxillofacial Surgery Clinic examines yearly more than 2200 new patients with various diseases arising in oral and maxillofacial regions. We provide a full range of services including tooth extraction, odontogenic/non-odontogenic infection, facial trauma, malformation, facial deformity, temporomandibular disorder, oral mucosal disease, and benign and malignant tumors. We have successfully treated oral cancer patients with lymphokine- activated killer/NK cell therapy and photodynamic therapy.

Research content

We conduct following research in order to develop new methods of diagnosis and therapy for diseases described above.

  1. Gene/ molecular diagnosis and therapy for oral cancer and salivary gland tumors. (cancer stem cells. growth factors, growth factor receptors, invasion and metastasis, tumor angiogenesis, molecular/ gene target therapy).
  2. Study on molecular/ genetic diagnosis and therapy for cranio-oral-maxillofacial deformities.
  3. Establishment and characterization of human induced pluripotent stem (iPS) cells derived from human pulp cells in serum-free cell culture.
  4. Generation of human induced pluripotent stem (iPS) cells derived from a patient with oral maxillofacial dysplasia, and clarifies the molecular mechanism involved in the disease.
  5. Functional study on biological active factors purified from marine products
  6. Study on photodynamic therapy for oral cancer
  7. Study on immune cell therapy for oral cancer by using activate NK/ lymphokine-activated killer cells (LAK) cells.
  8. Study on jaw and tooth regeneration in vitro. We have already succeeded to regenerate a jaw, eye and tooth through using undifferentiated pluripotent cells derived from Xenopus and mice. At present, we are conducting to regenerate a jaw, eye and tooth by using mouse ES cells, human mesenchymal stem cells and human iPS cells.
  9. Molecular-epidemiological study on oral-maxillofacial disease of the resident in Semipalatinsk Nuclear Test Site area in Kazakhstan.