Introduction of departments
The Oral and Maxillofacial Surgery Clinic examines yearly more than 2200 new patients with various diseases arising in oral and maxillofacial regions. We provide a full range of services including tooth extraction, odontogenic/non-odontogenic infection, facial trauma, malformation, facial deformity, temporomandibular disorder, oral mucosal disease, and benign and malignant tumors. We have successfully treated oral cancer patients with lymphokine- activated killer/NK cell therapy and photodynamic therapy.
We conduct following research in order to develop new methods of diagnosis and therapy for diseases described above.
- Gene/ molecular diagnosis and therapy for oral cancer and salivary gland tumors. (cancer stem cells. growth factors, growth factor receptors, invasion and metastasis, tumor angiogenesis, molecular/ gene target therapy).
- Study on molecular/ genetic diagnosis and therapy for cranio-oral-maxillofacial deformities.
- Establishment and characterization of human induced pluripotent stem (iPS) cells derived from human pulp cells in serum-free cell culture.
- Generation of human induced pluripotent stem (iPS) cells derived from a patient with oral maxillofacial dysplasia, and clarifies the molecular mechanism involved in the disease.
- Functional study on biological active factors purified from marine products
- Study on photodynamic therapy for oral cancer
- Study on immune cell therapy for oral cancer by using activate NK/ lymphokine-activated killer cells (LAK) cells.
- Study on jaw and tooth regeneration in vitro. We have already succeeded to regenerate a jaw, eye and tooth through using undifferentiated pluripotent cells derived from Xenopus and mice. At present, we are conducting to regenerate a jaw, eye and tooth by using mouse ES cells, human mesenchymal stem cells and human iPS cells.
- Molecular-epidemiological study on oral-maxillofacial disease of the resident in Semipalatinsk Nuclear Test Site area in Kazakhstan.