生命環境総合科学プログラム

石田 敦彦 教授 / ISHIDA Atsuhiko Professor

細胞内情報伝達、特にタンパク質リン酸化・脱リン酸化に興味を持ち、具体的にはCa2+情報伝達で重要な役割を果たす多機能性CaMキナーゼ及び、その制御に関わるCaMキナーゼホスファターゼを研究しています。

I am interested in intracellular signal transduction, especially protein phosphorylation and dephosphorylation. I am studying multifunctional CaM kinases, which play important roles in Ca2+ signaling, and CaM kinase phosphatase (PPM1F) involved in their regulation. The latter has been found to be involved in various diseases such as cancer and depression.

keywords:phosphorylation, dephosphorylation, biochemistry, molecular biology, chemical biology, enzyme inhibitor

  1. Autoactivation of C-terminally truncated Ca 2+ /calmodulin-dependent protein kinase(CaMK)Iδ via CaMK kinase-independent autophosphorylation Arch. Biochem. Biophys. 668 29 - 38(2019)
  2. Functions and dysfunctions of Ca2+ /calmodulin-dependent protein kinase phosphatase(CaMKP/PPM1F)and CaMKP-N/PPM1E Arch.Biochem. Biophys. 640 83 - 92(2018)
  3. The phosphatase-resistant isoform of CaMKI, Ca2+ /calmodulin-dependent protein kinase Iδ(CaMKIδ), remains in its 'Primed' form without Ca2+ stimulation. Biochemistry 54 3617 - 3630(2015)
浮穴 和義 教授 / UKENA Kazuyoshi Professor

私たちは、脳内の新しい調節因子を同定し、生体機能調節(特に食欲などの本能行動やエネルギー代謝調節)の脳内分子メカニズムを解明しようとしています。神経代謝調節学分野での新発見を目指しています。

I have identified novel neuropeptides in the avian and rodent brain and elucidate their molecular mechanisms, especially instinctive behavior such as appetite and regulation of energy metabolism. I am aiming for discoveries in the field of neurometabolic and neuroendocrine regulations. 

keywords:Neuropeptide, Energy metabolism, Neurometabolism, Neuroendocrinology

  1. Avian and murine neurosecretory protein GL participates in the regulation of feeding and energy metabolism. Gen. Comp. Endocrinol. 260:164-170 (2018) 
  2. Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity. eLife 6:e28527 (2017) 
  3. Neurosecretory protein GL, a hypothalamic small secretory protein, participates in energy homeostasis in male mice. Endocrinology 158:1120-1129 (2017)
久我 ゆかり 教授 / KUGA Yukari Professor

菌根共生における物質交換(植物C⇔菌根菌P,N,Cdなど)について様々な表面分析・細胞学的手法により明らかにしてきた。果樹類白紋羽病温水治療における土壌微生物相乗作用について明らかにしてきた。

My research themes are the symbioses between plants and soil fungi. Major topics are the mycorrhizal cellular functions using stable isotope tracers and nanoscale map SIMS and the decline mechanisms of the white root rot fungal pathogen associated with changes of soil microbial communities by the hot water treatment.

keywords:Symbioses, Soil-borne plant disease, Orchid mycorrhiza, Arbuscular mycorrhiza, Soil microbial community, Ultrastructure, Secondary ion mass spectrometry

  1. Allocation of Carbon from an Arbuscular Mycorrhizal Fungus, Gigaspora margarita, to Its Gram-Negative and Positive Endobacteria Revealed by High-Resolution Secondary Ion Mass Spectrometry. Microorganisms (2021)
  2. From imaging to functional traits in interactions between roots and microbes. In: Methods in Rhizosphere Biology Research. Springer (2019)
  3. Uptake and intraradical immobilization of cadmium by arbuscular mycorrhizal fungi as revealed by stable isotope tracer and synchrotron radiation µX-ray fluorescence analysis. Microbes Environ (2018)
佐藤 明子 教授 / SATOH Akiko Professor

細胞内における膜タンパク質の局在を決定する選別輸送機構の研究を行っています。ゴルジ体という細胞小器官が重要な役割を果たしますが、その分子機構について解明しようとしています。

Organelles maintain their shapes and functions as the equilibrium of membrane flow into and out of them. We are trying to identify the dynamics of Golgi apparatus, and understand its function on the biogenesis of the secretory and membrane proteins.

keywords:Golgi stacks, cisternae, Trans Golgi Network (TGN)

  1. Rab6 is required for multiple apical transport pathways but not for basolateral transport pathway in Drosophila photoreceptors/PLOS Genetics/2016
  2. Recycling endosomes are attached to trans-side of Golgi units both in Drosophila and mammalian cells/J. Cell Sci./2020
  3. Sec71 separates Golgi stacks in Drosophila S2 cells/J. Cell Sci./2020
竹田 一彦 教授 / TAKEDA Kazuhiko Professor

環境中の微量物質活性酸素マイクロプラスチックなどの分析方法の確立とそれらの地球環境に対する影響評価。 主に分析化学的プローチによる手法開発と、海洋や河川、大気などのフィールド調査の融合による研究。

I am a professional environmental scientist based on analytical chemistry in the aquatic environments and atmosphere. The current works are focused on photochemistry and their dynamics of 1) microplastics, 2) iodine, 3) reactive oxygen species, and 4) pollutants in environments. We are approaching these themes with laboratory work and fieldwork.

keywords:Analytical Chemistry, Environmental Chemistry, Microplastics, Iodine, Reactive Oxygen Species

  1. Migration of terephthalate from scraps of poly(ethylene terephthalate)(PET) in water and artificial seawater. Sci Total Environ 838: Article 156053 (2022)
  2. Factors controlling the degradation of hydrogen peroxide in river water, and the role of riverbed sand. Sci Total Environ 716: Article 136971 (2020)
  3. The iodide and iodate distribution in the Seto Inland Sea, Japan. Aquat Geochem 23: 315-330 (2017)
中坪 孝之 教授 / NAKATSUBO Takayuki Professor

河川流域北極ツンドラ硫気荒原などをフィールドに、生態系における個々の生物の役割を明らかにすることによって、 生態系の構造と機能の理解、環境変動が生態系に与える影響の予測を目指しています。

My research fields are ecosystem ecology and plant ecology. Recent research subject of my laboratory is the impact of alien species on the structure and function of ecosystems. In addition, I have been working on the impact of climate change on the Arctic terrestrial ecosystem for more than 20 years.

keywords:Alien species, Arctic, Climate change, Ecosystem ecology, Plant ecology

  1. Effects of climate warming on the production of the pioneer moss Racomitrium japonicum: seasonal and year-to-year variations/J. Plant Res./2021
  2. Annual respiration of Japanese mud snail Batillaria attramentaria in an intertidal flat: its impact on ecosystem carbon flows/Landsc. Ecol. Eng./2019
  3. Distribution and stress tolerance of Fimbristylis dichotoma subsp. podocarpa(Cyperaceae)growing in highly acidic solfatara fields/Ecol. Res./2018
古川 康雄 教授 / FURUKAWA Yasuo Professor

脳神経系の機能素子であるイオンチャネルの機能やシナプス伝達の可塑性に関する研究を行っている。現在は、主としてペプチド作動性Na+ チャネルと電位依存性K+ チャネルを対象とした研究を進めている。

We are interested in the structure and function of ion channels, which are membrane proteins permitting passive ion transport across the cell membrane. Ion channels are important determinants of neuronal excitability and plasticity. Currently, we are conducting research mainly on the peptide-gated Na+ channel and the voltage-gated K+ channels.

keywords:channel peptide excitability synapse

  1. Modulation of the FMRFamide-gated Na+ channel by external Ca2+, Pflugers Arch, 469:1335-1347 (2017)
  2. Serotonin modulates the excitatory synaptic transmission in the dentate granule cells, J Neurophysiol, 115:2997-3007 (2016)
  3. Electrostatic charge at position 552 affects the activation and permeation of FMRFamide-gated Na+ channels, J Physiol Sci, 64:141-150 (2014)
山崎 岳 教授 / YAMAZAKI Takeshi Professor

1)脳で合成されるステロイドホルモン(ニューロステロイド)の生理機能。特に女性ホルモン(エストラジオール)の神経保護作用について。2)メチル水銀の神経毒性に対する脂質の神経保護作用。

1) Physiological functions of steroid hormones synthesized in the brain (neurosteroids). Neuroprotective effect of sex steroid hormones. 2) Neuroprotective effect of polyunsaturated fatty acids on the neurotoxicity of methylmercury.

keywords:Neurosteroid, neuroprotection, estradiol

  1. DHA and Its metabolites have a protective role against methylmercury-induced neurotoxicity in mouse primary neuron and SH-SY5Y cells. Int J Mol Sci 22(6):3213 (2021)
  2. Potentiation of 17β-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid. Sci. Rep. 7:6268 (2017)
  3. De novo synthesized estradiol protects against methylmercury-induced neurotoxicity in cultured rat hippocampal slices. Pros One. 8:e55559 (2013)
山田 俊弘 教授 / YAMADA Toshihiro Professor

主に、インドネシアマレーシアミャンマーなどの熱帯林で研究をしています。熱帯林は生物多様性が高いことで知ら れています。私は、どの程度生物多様性が高いのか?、や、なぜ生物多様性が高いのか?について調べています。また、熱帯域は生物多様性の喪失が大きいことも知られています。生物多様性を保全する方策に関する研究も行っています。

I mainly study in tropical forests in Indonesia, Malaysia, Myanmar and so on. Tropical forests are known for their mega-biodiversities. At the same time, they are known for a large loss of biodiversity. I am conducting research on measures to conserve tropical biodiversity.

keywords:biodiversity, conservation biology, tropical rain forests

  1. The Forest Observation System, building a global reference dataset for remote sensing of forest biomass. Scientific data 6 (2019)
  2. TRY plant trait database – enhanced coverage and open access. Global Change Biology (2020)
  3. Dynamics of Tree Species Diversity in Unlogged and Selectively Logged Malaysian Forests. Scientific Reports 8:1024 (2018)

 

和崎 淳 教授 / WASAKI Jun Professor

植物の養分動態に関する研究を行っています。特に資源の枯渇が懸念されるリンに注目し、リン欠乏で形成されるクラスター根根分泌物による吸収機構の解明、リン利用効率の改善を目指した研究に取り組んでいます。

Main research topic is plant nutrition (especially phosphorus) and the dynamics in the rhizosphere.Strategies of P mobilization by plants are actively investigating, such as cluster root formation, root exudates, and plant-microbial interactions. We are also trying to apply the strategy on improvement of P use efficiency.

keywords:Rhizosphere, Phosphorus, Root Exudates, Cluster Roots

  1. AtALMT3 is involved in malate efflux induced by phosphorus deficiency in Arabidopsis thaliana root hairs. Plant Cell Physiol. 60: 107-115 (2019)
  2. P and N deficiency change the relative abundance and function of rhizosphere microorganisms during cluster root development of white lupin (Lupinus albus L.). Soil Sci. Plant Nutr. 64: 686-696. (2018)
  3. Formation of dauciform roots by Japanese native Cyperaceae and their contribution to phosphorus dynamics in soils. Plant Soil, 461:107- 118 (2021).
ヴィレヌーヴ 真澄美 教授 / VILLENEUVE Masumi Professor

界面に注目して熱力学ダイナミクスの観点から生命・環境の研究を行っています。具体的には、界面張力測定を主な手法として脂質膜相図を明らかにし、表面光散乱を測定して膜のダイナミクスを研究しています。

My research area is colloid and interface science. From materials to biomembranes, what we call soft matter is the subject of my research. Currently, I study the thermodynamics and dynamics of self-assembled monolayers at interfaces and the swelling mechanism of gluten-free, additive-free rice bread.

keywords:Colloid, Interface, Thermodynamics, Rheology, Surfactants, Lipids, Starch

  1. Roles of a-methyl trans-cyclopropane groups in behavior of mixed mycolic acid monolayers/BBA-Biomembrane 1861: 441 (2019)
  2. Uptake of iron (III)-ethylenediamine-N,N,N',N'-tetraacetic acid complex by phosphatidylcholine lipid film. Part II. Effect of film curvature/ Chem. Phys. Lipids 210: 14 (2018)
  3. Development of gluten-free rice bread: Pickering stabilization as a possible batter-swelling mechanism/LWt-Food Sci. Tech. 79: 632 (2017)
岩本 洋子 准教授 / IWAMOTO Yoko Associate Professor

大気中に浮遊する微粒子(エアロゾル)の研究を行っています。エアロゾルが地球の気候物質循環に与える影響を把握するため、海洋、山岳、都市、郊外などさまざまな場所で大気観測を行っています。

We are working on atmospheric aerosols. Aerosol particles can act as nuclei of cloud droplets, or can be a source of nutrients for plants on the sea/land surface. To understand the effects of aerosols on the global climate and biogeochemical cycles, we conduct atmospheric observations in various environments.

keywords:Aerosol, Climate, Cloud, Biogeochemical cycles

  1. Contribution of oceanic aerosol particles to cloud condensation nuclei, Earozoru Kenkyu, 35(3), 192-198, 2020
  2. Simultaneous measurement of CCN activity and chemical composition of fine-mode aerosols at Noto Peninsula, Japan, in autumn 2012/ Aerosol Air Qual. Res./2016
  3. Spatial variation of biogenic and crustal elements in suspended particulate matter from surface waters of the North Pacific and its marginal seas/Progr. Oceanogr./2014
土谷 彰男 准教授 / TSUCHIYA Akio Associate Professor

アマゾンの土地利用変化と地表面熱収支。林分の幹内蒸散流と牧場の蒸発散量。天然林とプランテーション林の分光放射特性。アマゾンの開発と環境。アマゾン生物圏大気圏大規模実験計画の研究誌。

Land use changes and heat balance components. Sap flow of capoeira and evapotranspiration over a pasture. Irradiance under a primary forest and an agricultural forest. Historical changes in Amazonian environemnts and the roles of Large-scale Biosphere-Atmosphere Experiments in Amazonia (LBA).

keywords:Amazon, Amazonia, environment, ambiente

 

  1. Differences in irradiance characteristics between Syzygium malaccense and Magnifera indica caused by their tree forms. Eco-habitat 27 (1): 65-74. (2021)
  2. Changes in CO2 concentration within shallow soils originating from solar radiation and rainwater in Central Amazonia. Jpn. J. Biometeor. 53-2: 93-93 (2016)
  3. Short-term responses of tree growth rings in natural gaps for forest management. In: F.M.B. Romero, R.B. Castro & J.C.R. Tello (eds), Estudos dendrológicos e ecológicos na Amazônia: oportunidades e experiências, 66-86. INPA, Manaus, Brazil. (2022)
中林 雅 准教授 / NAKABAYASHI Miyabi Associate Professor

野外調査によって、おもに哺乳類生態行動を研究しています。送粉や種子散布など、植物と動物の相互作用にも着目しています。

We study on ecology and behavior of animals, mainly mammals, by field work. We also focus on plant-animal interactions such as seed dispersal and pollination.

keywords:Mammal, Ecology, Behavior, Field work

  1. Temporal activity patterns suggesting niche partitioning of sympatric carnivores in Borneo, Malaysia. Sci Rep 11: 19819 (2021)
  2. Limited directed seed dispersal in the canopy as one of the determinants of the low hemi-epiphytic figs’ recruitments in Bornean rainforests. PLOS ONE: pone.0217590 (2019)
  3. Horizontal habitat preference of three sympatric Paradoxurinae civet species in a small area in Sabah, Malaysian Borneo. Eur J Wildl Res 63: 2 (2017)
根平 達夫 准教授 / NEHIRA Tatsuo Associate Professor

有機合成化学構造有機化学を基盤に、生命科学への貢献を目指している。酵素を機能特異的に認識する蛍光プローブの合成、円二色性を利用した分子の立体構造解析、天然有機化合物の構造解析をしている。

Life science is explored by organic chemistry, specifically, organic synthesis and organic structure analysis. Synthesis of useful probes, chirality analysis by circular dichroism, and structure elucidation of natural products are conducted.

keywords:Organic synthesis, Structural organic chemistry, Natural product chemistry, Circular dichroism

  1. Development of a Universal Ellipsoidal Mirror Device for Fluorescence Detected Circular Dichroism (FDCD) – Elimination of Polarization Artifacts, Appl Spectr 59: 121-125 (2005)
  2. A sensitive method based on fluorescence-detected circular dichroism for protein local structure analysis, Anal Biochem 430: 179-184 (2012)
  3. Natural Dolapyrrolidone: Isolation and Absolute Stereochemistry of a Substructure of Bioactive Peptides, Chirality 32: 1152-1159 (2020)
彦坂 暁 准教授 / HIKOSAKA Akira Associate Professor

無腸動物を用いて動物の初期進化個体発生の進化藻類との共生進化、等を研究している。同時に瀬戸内海産の無腸動物ナイカイムチョウウズムシを実験に使いやすくするための基盤整備も進めている。

We are studying the early evolution of animals, the evolution of ontogeny, and the evolution of endosymbiosis with microalgae using an acoel flatworm, Praesagittifera naikaiensis, living in the Seto Inland Sea.

keywords:Acoela, Evolution, Endosymbiosis, Seto Inland Sea, Praesagittifera naikaiensis

  1. Geographical Distribution and Genetic Diversity of Praesagittifera naikaiensis(Acoelomorpha) in the Seto Inland Sea, Japan. Zool Sci 37:314–9. (2020)
  2. Multiple massive domestication and recent amplification of Kolobok superfamily transposons in the clawed frog Xenopus. Zoological Lett 4:17. (2018)
  3. Genome evolution in the allotetraploid frog Xenopus laevis. Nature 538:336–343. (2016)
渡邊 千穂 准教授 / WATANABE Chiho Associate Professor

物質的な側面から生命や疾病を読み解くことを目指し、生体膜を模倣したリポソームや高分子液滴(エマルション)などのin vitro細胞モデル(人工細胞)を用いたプロジェクトに取り組んでいます。

I work on projects using in vitro cell models (artificial cells) such as polymer solutions, polymer droplets (emulsions), and liposomes (lipid membranes). My aim is to understand “life” from materials and explore connections between them. I am currently interested in neurodegenerative disease and lipid roles in liquid-liquid phase separation.

keywords:lipid membrane, artificial cell, polymer solutions, liposomes, emulsions

  1. Membrane Surface Modulates Slow Diffusion in Small Crowded Droplets /Langmuir/2021
  2. Quantitative Analysis of Membrane Surface and Small Confinement Effects on Molecular Diffusion/J. Phys. Chem. B/2020
  3. On the possible structural role of single chain sphingolipids Sphingosine and Sphingosine 1-phosphate in the amyloid-β peptide interactions with membranes. Consequences for Alzheimer’s disease development/Colloids Surf. A/2016
戸田 求 講師 / TODA Motomu Associate Professor or Lecturer

主要研究課題:森林生態系を対象としたエネルギー・炭素循環 研究手法:野外観測、数値モデルシミュレーション、デジタル画像解析など 近年の研究課題:(a)気候変動に関連する自然撹乱からの生態系応答(b)老齢林の高い炭素吸 収量を生み出すメカニズム解明 (c)デジタル画像処理を駆使した森林生態系の機能・構造評価

My research interests are biosphere-atmosphere interaction, carbon and water cycle in terrestrial ecosystems, Digital visualisation of canopy structure, near-surface remote sensing operations and process-based ecosystem modeling.

keywords:Terrestrial carbon cycle, Macro- and micro-climates; Atmosphere–forest dynamics modeling, Climate change

  1. A Bayesian framework to evaluate parameter and predictive inference of a simple soil respiration model in a temperate forest in western Japan. Ecological Modelling(2020)
  2. Estimation of plant area index and phenological transition dates from digital repeat photography and radiometric approaches in a hardwood forest in the Northeastern United States. Agricultural and Forest Meteorology(2017)
  3. Single level turbulence measurements to determine roughness parameters of complex terrain. Journal of Geophysical ResearchAtmosphere)(2003)
勝山 千恵 助教 / KATSUYAMA Chie Assistant Professor

土壌微生物による物質動態に関する研究:菌根菌、その内生細菌植物病原菌およびこれら真菌の菌糸周辺土壌微生物を対象に、安定同位体トレーサー法により物質変換・移動機構と生物間相互作用の解明を目指しています。

My research themes are element cycles and dynamics caused by soil microorganisms. I am trying to elucidate the interactions between soil microorganisms, such as a mycorrhizal fungus, endobacteria, a fungal pathogen, and soil bacteria and fungi around fungal hyphae (hyphosphere), by using stable isotope tracers and microbial ecological methods.

keywords:Soil microorganisms, White root rot fungal pathogen, Mycorrhiza, Endobacteria, Hyphosphere, Element cycle, Stable isotope tracer, Gas chromatography/mass spectrometry (GC/MS), Microbial ecology

  1. Overview of recent researches on nitrifying microorganisms in soil. Soil Sci Plant Nutr 67: 619-632. (2021)
  2. Occurrence and potential activity of denitrifiers and methanogens in groundwater at 140 m depth in Pliocene diatomaceous mudstone of northern Japan. FEMS Microbiol Ecol 86: 532-543. (2013)
  3. Allocation of carbon from an arbuscular mycorrhizal fungus, Gigaspora margarita, to its gram-negative and positive endobacteria revealed by high-resolution secondary ion mass spectrometry. Microorganisms 9: 2597. (2021)
小林 勇喜 特定准教授 / KOBAYASHI Yuuki Associate Professor(Special Recognition)

受容体は細胞膜に発現するのが当たり前?百年以上忘れ去られた一次繊毛というオルガネラに発現する摂食情動睡眠等に関係する受容体に着目し研究を行っています。細胞から個体を通して真の生命現象に迫ります。

Although G protein-coupled receptors (GPCRs) play important roles as receptors that mediate various life phenomena, a detailed understanding of their functions is limited. Main recent research topic is analysis of GPCRs localized in primary cilia. We are aiming for a breakthrough in the field of neuroscience.

keywords:GPCR, primary cilia, endocrinology, neuroscience

  1. Properties of primary cilia in melanin-concentrating hormone receptor 1-bearing hippocampal neurons in vivo and in vitro. Neurochem Int 142 : 104902. (2021)
  2. New perspectives on GPCRs: GPCR heterodimer formation (melanocortin receptor) and GPCR on primary cilia (melanin concentrating hormone receptor). Gen Comp Endocrinol 293 : 114474. (2020)
  3. Characterization of functional primary cilia in human induced pluripotent stem cell-derived neurons. Neurochem Res 44 : 1736–1744. (2019)
中川 直樹 助教 / NAKAGAWA Naoki Assistant Professor

植物のミトコンドリア機能が変化した変異体と植物成長調節剤を用い、これまでミトコンドリアとの関連が見落とされていた様々な形質とミトコンドリアの関連を明らかにし、役立てることを目標にしている。

Using mutants with altered plant mitochondrial function and plant growth regulators, we aim to clarify the relationship between mitochondria and various traits that have been overlooked.

keywords:plant hormone

  1. The putative peptide gene FEP1 regulates iron deficiency response in Arabidopsis. Plant Cell Physiol. 59: 1739-52 (2018)
  2. Sugar treatment inhibits IAA‐induced expression of endo‐1,3:1,4‐β‐glucanase EI transcripts in barley coleoptile segments Physiol. Planta. 139: 413-420 (2010)
  3. A mutation in At-nMat1a, which encodes a nuclear gene having high similarity to group II intron maturase, causes impaired splicing of mitochondrial NAD4 transcript and altered carbon metabolism in Arabidopsis thaliana. Plant Cell Physiol. 47: 772 - 83 (2006)
成松 勇樹 助教 / NARIMATSU Yuki Assistant Professor

脳内に存在する特定の調節因子や神経が、動物の摂食行動脂肪蓄積を制御する仕組みについて研究しています。将来的には、ヒトの肥満生活習慣病問題の解決に貢献したいと考えています。

We are interested in the mechanisms through which neuropeptides and neurons existing within the brain govern an animal's feeding behavior and fat accumulation. We aim to contribute to resolving issues related to obesity and metabolic diseases in the future.

keywords:Neuroendocrinology, Energy metabolism, Obesity, Metabolic diseases

  1. Hypothalamic Overexpression of Neurosecretory Protein GL Leads to Obesity in Male C57BL/6J Mice.Neuroendocrinology 112:606–620 (2022)
  2. Neurosecretory Protein GL Accelerates Liver Steatosis in Mice Fed Medium-Fat/Medium-Fructose Diet. Int J Mol Sci 23:2071 (2022)
  3. Subcutaneous infusion of neurosecretory protein GL promotes fat accumulation in mice. 7:e07502 (2021)
平野 哲男 助教 / HIRANO Tetsuo Assistant Professor

謎の多い存在「ノンコーディングRNA」の一つであるCCDC26-RNAについて、骨髄性白血病細胞のがん化に関係があることや赤血球細胞の発生段階特異的な遺伝子制御に関連していることを明らかにしました。

I have discovered that CCDC26-RNA, one of the enigmatic "non-coding RNAs", is involved in the oncogenic transformation of myeloid leukemia cells. Interestingly, I have recently found that this molecule is also involved in developmental stage-specific gene regulation of erythroid cells.

keywords:tumorigenesis, double minute chromosomes, gene amplification, leukemia, mt DNA, HL-60

  1. Long noncoding RNA CCDC26 as a modulator of transcriptional switching between fetal and embryonic globins./BBA- MCR/2021 
  2. Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression./Mol.Cancer/2015 
  3. Genes encoded within 8q24 on the amplicon of a large extrachromosomal element are selectively repressed during the terminal differentiation of HL-60 cells./Mutat.Res./2008


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