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水沼正樹、益村晃司、金井宗良
長寿変異株SSG1変異株の特徴からみる酵母寿命の関連因子
日本醸造協会誌、印刷中.
水沼正樹
栄養・代謝センシング経路による寿命制御機構
生化学（日本生化学会）、90巻、３号、印刷中.
中村 諒、中野久美子、田村博康、水沼正樹、伏木 亨、平田 大
料理とともに味わう日本酒のおいしさの評価（新たな試み）
日本醸造協会誌、第113巻、5号、印刷中.
2017
K. Kume, H. Cantwell, F.R. Neumann, A.W. Jones, A.P. Snijders, and P. Nurse
A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nucelar size control.
PLoS Genet., 13(5):e1006767, (2017).
M. Kanai, M. Mizunuma, T. Fujii, and H. Iefuji
A genetic method to enhance the accumulation of S-adenosylmethionine in yeast.
Appl. Microbiol. Biotechnol., 101, 1351-1357 (2017).
K. Kume, T. Hashimoto, M. Suzuki, M. Mizunuma, T. Toda, and D. Hirata
Identification of three signaling molecules required for calcineurin-dependent monopolar growth induced by the DNA replication checkpoint in fission yeast.
Biochem. Biophys. Res. Commun., 491, 883-889 (2017).
M. Kanai, T. Kawata, Y. Yoshida, Y. Kita, T. Ogawa, M. Mizunuma, D. Watanabe, H. Shimoi, A. Mizuno, O. Yamada, T. Fujii, and H. Iefuji
Sake yeast YHR032W/ERC1 haplotype contributes to high S-adenosylmethionine accumulation in sake yeast strains.
J. Biosci. Bioeng., 123, 8-14 (2017).
R. Nakamura, K. Nakano, H. Tamura, M. Mizunuma, R. Fushiki, and D. Hirata
Evaluation of the comprehensive palatability of Japanese sake paired with dishes by multiple regression analysis based on subdomains.
Biosci. Biotechnol. Biochem., 81, 1598-1606 (2017).
M. Yukawa, T. Kawakami, M. Okazaki, K. Kume, N.H. Tang, and T. Toda
A microtubule polymerase cooperates with the kinesin-6 motor and a microtubule cross-linker to promote bipolar spindle assembly in the absence of kinesin-5 and kinesin-14 in fission yeast.
Mol. Biol. Cell, 28(25), 3647-3659 (2017).
小川貴史、水沼正樹
メチオニン代謝が鍵となる酵母の長寿の仕組み
化学と生物（日本農芸化学会）、55巻、8号、526-528（2017）.
小川貴裕、小寺幸広、水沼正樹
モデル生物線虫C. elegansを用いた熟成ニンニクの機能解析
化学と生物（日本農芸化学会）、55巻、6号、372-374（2017）.
2016
T. Ogawa, R. Tsubakiyama, M. Kanai, T. Koyama, T. Fujii, H. Iefuji, T. Soga, K. Kume, T. Miyakawa, D. Hirata, and M. Mizunuma
Stimukating S-adenosyl-L-methionine synthesis extends lifespan via activation of AMPK.
Proc Natl Acad Sci USA, 113(42), 11913-11918, (2016).
T. Ogawa, Y. Kodera, D. Hirata, TK Blackwell, and M. Mizunuma
Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf.
Sci Rep., 2016; 6: 21611. doi: 10.1038/srep21611 (2016).
I. Nunez, M. R. Pino, D. J. Wiley, M. E. Das, C. Chen, T. Goshima, K. Kume, D. Hirata, T. Toda, and F. Verde
Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5
Elife, 2016 Jul 30;5. pii: e14216. (2016).
T. Goshima, R. Nakamura, K. Kume, H. Okada, E. Ichikawa, H. Tamura, H. Hasuda, M. Inahashi, N. Okazaki, T. Akao, H. Shimoi, M. Mizunuma, Y. Ohya, and D. Hirata
Identification of a mutation causing a defective spindle assembly checkpoint in high ethyl caproate-producing sake yeast strain K1801.
Biosci. Biotechnol. Biochem., 80 (8), 1657-1667 (2016).
K. Kume
Elutriation for cell cycle synchronization in fission yeast.
2015
T. Koyano, K. Barnouin, A. Snijders, K. Kume, D. Hirata, and T. Toda
Casein kinase 1γ acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast.
Genes Cells, 20(12), 1046-1058, (2015).
K. Wan, H. Kawara, T. Yamamoto, K. Kume, Y. Yabuki, T.Goshima, K. Kitamura, M. Ueno, M. Kanai, D. Hirata, K. Funato, K. Mizuta
The essential function of Rrs1 in ribosome biogenesis in conserved in budding and fission yeasts.
Yeast, 32(9), 607-614, (2015).
T. Koyano, M. Konishi, SG Martin, Y. Ohya, D. Hirata, T. Toda, and K. Kume
Casein Kinase 1γ ensures monopolar growth polarity under incomplete DNA replication downstream of Cds1 and Calcineurin in fission yeast.
Mol. Cell. Biol., 35(9), 1533-42 (2015).
H. Tamura, H. Okada, K. Kume, T. Koyano, T. Goshima, R. Nakamura, T. Akao, H. Shimoi, M. Mizunuma, Y. Ohya and D. Hirata
Isolation of a spontaneous cerulenin-resistant sake yeast with both high ethyl caproate-producing ability and normal checkpoint integrity.
Biosci. Biotechnol. Biochem. 79(7), 1191-1199, (2015).
K. Kume, T. Koyano, J. Takata, K. Wakabayashi, M. Mizunuma, T. Miyakawa and D. Hirata
Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application for a positive screening for drugs inhibiting calcineurin.
Biosci. Biotechnol. Biochem. 79(5), 790-794, (2015).
田村博康、栗林 喬、久米一規、五島徹也、中村 諒、渡邊健一、赤尾 健、下飯 仁、水沼正樹、平田 大
カプロン酸エチル高生産性清酒酵母の迅速識別法
日本醸造協会誌、第110巻、12号、820-826.
2014
M. Mizunuma, E. Neumann-Haefelin, N. Moroz, Y. LI and T. K. Blackwell
mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity.
Aging Cell, 13, 869-878 (2014)
Y. Anzawa, K. Satoh, Y. Satoh, S. Ohno, T. Watanabe, K. Katsumata, K. Kume, K. Watanabe, M. Mizunuma, and D. Hirata
Late-maturing cooking rice Sensyuraku has excellent properties, equivalent to sake rice, for high-quality sake brewing.
2013
M. Mizunuma, R. Tsubakiyama, T. Ogawa, A. Shitamukai, Y. Kobayashi, T. Inai, K. Kume, and D. Hirata
Ras/cAMP-dependent protein kinase (PKA) regulates multiple aspects of cellular events by phosphorylating the Whi3 cell cycle regulator in budding yeast.
J. Biol. Chem., 288, 10558-10566 (2013)
K. Kume, S. Kubota, T. Koyano, M. Kanai, M. Mizunuma, T. Toda, and D. Hirata
Fission yeast leucine-rich repeat protein Lrp1 is essential for cell morphogenesis as a component of the morphogenesis Orb6 network (MOR).
Biosci. Biotechnol. Biochem., 77, 1086-1091 (2013)
M. Mizunuma, T. Ogawa, T. Koyama, A. Shitamukai, R. Tsubakiyama, T. Komaruyama, T. Yamaguchi, K. Kume, and D. Hirata
Evidence of antagonistic regulation of restart from G1 delay in response to osmotic stress by the Hog1 and Whi3 in budding yeast.
Biosci. Biotechnol. Biochem., 77, 2002-2007 (2013)
Y. Anzawa, Y. Nabekura, K. Satoh, Y. Satoh, S. Ohno, T. Watababe, M. Kaneoke, K. Kume, M. Mizunuma, K. Watanabe, K. Katsumata, and D. Hirata
Polishing properties of sake rice Koshitanrei for high-quality sake brewing.
Biosci. Biotechnol. Biochem., 77, 2160-2165 (2013)
T. Kuribayashi, H. Tamura, K. Sato, Y. Nabekura, T. Aoki, Y. Anzawa, K. Katsumata, S. Ohdaira, S. Yamashita, K. Kume, M. Kaneoke, K. Watanabe, and D. Hirata
Isolation of a non-urea-producing sake yeast strain carrying a discriminable molecular marker.
Biosci. Biotechnol. Biochem., 77, 2505-2509 (2013)
N. Aburai, J. Yoshida, M. Kobayashi, M. Mizunuma, M. Ohnishi and K. Kimura
Pisferidiol restores the growth of a mutant yeast suffering from hyperactivated Ca2+ signaling through calcineurin inhibition.
2012
S. Robida-Stubbs, K. Glover-Cutter, D. W. Lamming, M. Mizunuma, S. D. Narasimham, D. Neumann-Hawfelin, D. M. Sabatini, and T. K. Blackwell
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
Cell Metab., 15, 713-724 (2012)
T. Kuribayashi, M. Kaneoke, D. Hirata and K. Watanabe
Analysis of free fatty acids in sake by an enzymatic method and its application for estimating ethyl caproate and selecting yeast with high productivity of the ester.
Biosci. Biotechnol. Biochem., 76, 391-394 (2012)
S. Ohnuki, T. Kobayashi, H. Ogawa, I. Kozone J. Ueda, M. Takagi, K. Shin-ya, D. Hirata, S. Nogami and Y. Ohya
Analysis of the biological activity of a novel 24-membered macrolide JBIR-19 in Saccharomyces cerevisiae by the morphological imaging program CalMorph.
2011
R. Tsubakiyama, M. Mizunuma, A. Gemgyo, J. Yamamoto, K. Kume, T. Miyakawa, and D. Hirata
Implication of Ca2+ in the regulation of replicative life span of budding yeast.
J. Biol. Chem., 286, 28681-7 (2011)
K. Kume, T. Koyano, M. Kanai, T. Toda, and D. Hirata
Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth.
Nat. Cell Biol., 13, 234-42 (2011)
C. Ikebe, M. Konishi, D. Hirata, T. Matsusaka, and T. Toda
Systematic localization study on novel proteins encoded by meiotically up-regulated ORFs in fission yeast.
Biosci. Biotechnol. Biochem., 75, 2364-2370 (2011)
S. Kawamoto, M. Kaneoke, K. Ohkouchi, Y. Amano, Y. Takaoka, K. Kume, T. Aki, S. Yamashita, K. Watanabe, M. Kadowaki, D. Hirata, and K. Ono
Sake lees fermented with lactic acid bacteria prevents allergic rhinitis-like symptoms and IgE-mediated basophil degranulation.
2010
T. Goshima, K. Kume, T. Koyano, Y. Ohya, T. Toda, and D. Hirata
Fission yeast germinal center (GC) kinase Ppk11 interacts with Pmo25 and plays an auxiliary role in concert with the morphogenesis Orb6 network (MOR) in cell morphogenesis.
J. Biol. Chem., 285, 35196-205 (2010)
S. Ray, K. Kume, S. Gupta, W. Ge, M. Balasubramanian, D. Hirata, and D. McCollum
The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe.
J. Cell. Biol., 190, 793-805 (2010)
T. Koyano, K. Kume, M. Konishi, T. Toda, and D. Hirata
Search for kinases related to transition of growth polarity in fission yeast.
Biosci. Biotechnol. Biochem., 74, 1129-33 (2010)
S. Attrapadung, J. Yoshida, K. Kimura, M. Mizunuma, T. Miyakawa, and B.W. Thanomsub
Identification of ricinoileic acid as an inhibitor of Ca2+ signal-mediated cell-cycle regulation in budding yeast.
2009
A. Ano, D. Suehiro, K. Cha-aim, K. Aritomi, P. Phonimdaeng, N. Nontasa, H. Hoshida, M. Mizunuma, T. Miyakawa, and R. Akada
Combinatorial gene overexpression and recessive mutant gene introduction in sake yeast.
