Our research focuses on the physiological functions of food factors such as probiotics, prebiotics and polyphenols for our health.
1) Diseases induced by high-fat diets and environmental stresses are recognized as most important health problems all over the world. We are interested in these pathogenesis and the preventive roles of food factors such as prebiotics and polyphenols against these diseases (T. Suzuki).
2) We have been studying about immune regulatory effect of factors derived from food and effective microorganism for development of functional food (Y. Yamamoto).
Yogurt, Lactic acid bacteria, Oligosaccharide, Polyphenol
In vitro assay using human gastrointestinal Caco-2 cells
An immunofluorescence image of a tight junction protein in the rat colon
Yamamoto Y, Sugimura R, Watanabe T, Shigemori S, Okajima T, Nigar S, Nanai F, Sato T, Ogita T, Shimosato T. (2017) Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase. Front Immunol. 8: 1049.
Nigar S, Yamamoto Y, Okajima T, Shigemori S, Sato T, Ogita T, Shimosato T. (2017)(Co-first author) Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production. BMC Immunol. 18: 44.
Yamamoto Y, Shigemori S, Sato T, Nigar S, Oshiro K, Wang Y, Shimosato T. (2016) Development of a simple IgE-independent anaphylactic model using buckwheat antigen and B-type CpG oligodeoxynucleotide from Streptococcus thermophilus. Anmi Sci J. 87, 5: 710-717.
Wang Y, Yamamoto Y, Shigemori S, Watanabe T, Oshiro K, Wang P, Sato T, Yonekura S, Tanaka S, Kitazawa H, Shimosato T. (2014) (Co-first author) Inhibitory/Suppressive Oligodeoxynucleotide Nanocapsules as Simple Oral Delivery Devices for Preventing Atopic Dermatitis in Mice. Mol Ther. 23: 297-309.
Suzuki T.(2013) Regulation of intestinal epithelial permeability by tight junctions. Cell Mol Life Sci.70(4):631-59.
Azuma T, Shigeshiro M, Kodama M, Tanabe S, Suzuki T.(2013) Supplemental naringenin prevents intestinal barrier defects and inflammation in colitic mice. J Nutr. 143(6):827-34.
Noda S, Tanabe S, Suzuki T. (2013) Naringenin enhances intestinal barrier function through the expression and cytoskeletal association of tight junction proteins in Caco-2 cells. Mol Nutr Food Res. In press.
Suzuki T, Elias BC, Seth A, Shen L, Turner JR, Giorgianni F, Desiderio D, Guntaka R, and Rao RK.(2009) PKC eta regulates occludin phosphorylation and epithelial tight junction integrity. Proc Natl Acad Sci USA 106: 61-66.