Laboratory for Hepatology Research
　Viral Hepatitis, cirrhosis, carcinoma of liver, autoimmune hepatitis, primary biliary cirrhosis, fatty liver, non-alcoholic steatohepatitis, gastroesophageal varices, acute liver failure, etc.
Laboratory for Pancreas Research
　Carcinoma of pancreas, biliary cancer, bile duct cancer, cystic fibrosis of the pancreas, acute pancreatitis, autoimmune pancreatitis, cholecystitis, cholangitis, cholelithiasis, etc.
Laboratory for Research of the Gastrointestinal Tract
　Carcinoma of the esophagus, carcinoma of the stomach, bowel cancer, lymphoma malignum, various kinds of alimentary canal tumor, esophagitis, gastritis, gastric and duodenal ulcer, disease of the small bowel, inflammatory bowel disease, functional gastrointestinal tract disturbance, etc.

Clinical research

1. Approaches to improve the effect of interferon therapy for chronic hepatitis C
2. Approaches in antiviral therapy for chronic hepatitis B
3. Approaches to long-term improvement with precise diagnosis and multimodality therapy for hepatocarcinoma
4. Development of new diagnostic method and new treatment for carcinoma of liver
5. Approaches in epidemiological studies and therapy for NAFLD and NASH

Basic research

1. Exploration of factors relating to antiviral effect for viral hepatitis
2. Construction of evaluation system of drug efficacy by use of human hepatocyte chimeric mice
3. Elucidation of molecular mechanism of NAFLD/NASH and exploration of new therapies for it

Clinical research

1. Searching of markers for early recognition of post-ERCP pancreatitis
2. Evaluation of effects of stent for pancreatic duct to prevent post-ERCP pancreatitis
3. Construction of new intubation with guidewire used at the time of ERCP
4. Evaluation of concurrent chemoradiotherapy used with anticancer drug other than Gem/S-1 to treat with advanced pancreatic cancer
5. Endoscopic treatment for malignant duodenal stenosis

Basic research

1. Searching of diagnostic marker for pancreatic cancer by use of clinical specimen and cell line of pancreatic cancer
2. Elucidation of mechanism of pancreatic cancer development by use of cell line of pancreatic cancer

Clinical research

1. Construction of diagnostic morphology in cancer in the digestive tract by use of high-magnification endoscopic surveillance with Image Enhanced Endoscopy (IEE) such as NBI/FICE and so on
2. Molecular pathologic and immunological analyses by use of endoscopic resection specimens
3. Development of new endoscopic instruments and erection of new method of image analysis by academic-industrial cooperation
4. Research on new endoscopic diagnosis and therapeutic technique and development of instruments
5. Development of diagnostics of gastrointestinal tract with external ultrasound
6. Medication to treat diseases of gastrointestinal tract

Basic research

1. Elucidation of mechanism of development, invasion and metastasis of gastrointestinal tract tumor and cancer and therapeutic application of the findings
2. Elucidation of pathological conditions of inflammatory bowel disease
3. Molecular biological analysis of Helicobacter pylori related disease
4. Relevance between gastrointestinal hormone, secretion of acid and NO production and chronic inflammation of gastrointestinal tract

Annual numbers of Hepatic examinations and treatments
Inpatients for liver diseases: 1,200 cases
Antiviral therapy against hepatitis B and hepatitis C: 350 cases
Treatment for liver cancer:  750 cases
  Radiofrequency ablation: 50 cases
  Transcatheter arterial chemoembolization (TACE): 450 cases
  Reservoir hepatic arterial infusion chemotherapy: 90 cases
  Systemic chemotherapy: 60 cases
  Endoscopic therapy or IVR for gastroesophageal varices (EVL, EIS, BRTO etc): 50 cases
  Liver biopsy: 100 cases
  Treatment for NAFLD/NASH:  650 cases