In February 2010, Hiroshima University concluded an inter-university exchange agreement with Vietnam National University, Ho Chi Minh City (VNU-HCM); in November the same year, it established the Hiroshima University Vietnam Center at the Ho Chi Minh City University of Social Sciences and Humanities, which is part of VNU-HCM, in order to serve as a base for exchange at that university.

One of two national universities in Vietnam, VNU-HCM is a general university that serves as an umbrella organization for a number of universities, including the Ho Chi Minh City University of Technology, the Ho Chi Minh City University of Science, the Ho Chi Minh City University of Social Sciences and Humanities, the Ho Chi Minh City International University, and the Ho Chi Minh City University of Information Technology. In addition, Ho Chi Minh City is home to a number of other universities with which Hiroshima University has concluded exchange agreements, such as the Ho Chi Minh City Medicine and Pharmacy University, so it is anticipated that wide-ranging academic exchange will take place.

More specifically, it is gradually beginning to play a part as a base for securing international students from Vietnam, an in-country point of contact for students from Hiroshima University going to Vietnam to study or undertake training, a focus for academic exchange between Japan and Vietnam, a support base for cultural exchange activities and promoting teaching and learning of the Japanese language and Japanese studies in Vietnam, and a hub for the activities of the Hiroshima University Vietnam Alumni Association.

The 5th Japanese Essay Speech Contest Held Online in Vietnam and Japan (Mar. 2022)
The 4th Japanese Essay Speech Contest Held Online in Vietnam and Japan (Apr. 2021)
HU participates in the May Festival at USSH (May 2019)
The 61st START Program (Vietnam) held (Mar. 2019)
The 3rd Japanese Essay Speech Contest Held in Vietnam (Mar. 2019)
HU participates in the May Festival at USSH (May 2018)
The 2nd Japanese Essay Speech Contest Held in Vietnam (Mar. 2018)
The 2nd Hiroshima-Ho Chi Minh City Triple Helix Collaboration Seminar (Aug. 2017)
HU participates in the May Festival at USSH (May 2017)
The First Japanese  Essay Speech Contest Held in Vietnam（Feb. 2017）
The 37th START Program (Vietnam) held (Feb. 2017)
The 1st Seminar on Environment in Vietnam: For Resolution of Environmental Issues was held (Aug. 2016)
The 30th START Program (Vietnam) held (Mar. 2016)
Memories of Study Abroad (Interview): Nguyen Tien Luc (Nov. 2015)
HU participates in the May Festival at USSH (May 2015)
The 22nd START Program (Vietnam) held (Mar. 2015)
HU holds Northern Vietnam Alumni Meeting (Jan. 2015)
HU Invites USSH President Sen and Prof. Luc for its Homecoming Day (Japanese page) (Nov. 2013)
HU participates in the May Festival at USSH (May 2012)
Hiroshima University Vietnam Center established in Ho Chi Minh (Japanese page) (Dec. 2010)
HU concluded an agreement with Vietnam National University Ho Chi Minh City (Feb. 2010)